Neuromodulation for a Novel OCD Biomarker and Treatment (NCT05994053)
🩺 Plain-English Summary (8th-Grade Level)
Although multiple treatments for OCD exist, slow symptom decrease, high remission, and significant side effects for some OCD patients limit their efficacy. More research into the precise neural mechanisms and linked cognitive functions in OCD is also necessary. To address both concerns, this study by Dr. Reinhart and his team will test a new, non-invasive, and well-tolerated neuromodulation method for reducing OCD symptoms, based on reward-related rhythms of the orbitofrontal cortex (OFC; a brain region responsible for reward, decision making and other crucial functions that is affected by OCD). This proposal is based on highly encouraging preliminary data in both subsyndromal and treatment-resistant populations that shows rapid reductions in OCD behaviors that last at least 1-3 months. Using high-definition transcranial alternating current stimulation (HD-tACS) guided by EEG brain wave recordings, the study will test whether repetitive modulation of relevant rhythm activity in the OFC can lead to rapid (within five days) and sustainable (up to three months) OCD symptom reduction. This research aims to increase knowledge of OCD and development of effective treatment with minimal side effects.
Who can join: Review the eligibility criteria below.
Location: Boston University Center for Anxiety and Related Disorders (BU-CARD) — Boston, Massachusetts
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Boston University Center for Anxiety and Related Disorders (BU-CARD) — Boston, Massachusetts
📞 Contact the Study Coordinator
Phone: (617) 353-9481
Email: rmgr@bu.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in OCD
- Measuring Automated Behavioral Observations & Vocal Expressions (ABOVE) — Pittsburgh, Pennsylvania
- Open/Aftercare Treatment for Participants Diagnosed With Obsessive Compulsive Disorder — Stanford, California
- Locating Biomarkers in OCD Through Behavioral Tasks — Pittsburgh, Pennsylvania
- How Hormones and Exposure and Response Prevention (EX/RP) Affect the Brain of People With OCD — New York, New York
- Safety and Feasibility of FUS Next Generation Dome Helmet (NGDH) to Perform Neuromodulation in Patients With Treatment Refractory Obsessive Compulsive Disorder (OCD) — Toronto, Ontario
Explore by condition: All OCD clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.