A Study to Investigate the Efficacy of Durvalumab Plus Tremelimumab in Combination With Chemotherapy Compared With Pembrolizumab in Combination With Chemotherapy in Metastatic NSCLC Patients With Non-squamous Histology Who Have Mutations and/or Co-mutations in STK11, KEAP1, or KRAS (NCT06008093)
A Phase IIb, Randomized, Multicenter, Open-label Study to Assess the Efficacy of Durvalumab Plus Tremelimumab Versus Pembrolizumab in Combination With Platinum-based Chemotherapy for First-line Treatment in Metastatic Non-small Cell Lung Cancer Patients With Non-squamous Histology Who Have Mutations and/or Co-mutations in STK11, KEAP1, or KRAS (TRITON)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of the study is to assess the efficacy of durvalumab plus tremelimumab in combination with chemotherapy compared with pembrolizumab in combination with chemotherapy in metastatic NSCLC patients with non-squamous histology who have mutations and/or co-mutations in STK11, KEAP1, or KRAS.
Who can join: Review the eligibility criteria below.
Location: Research Site — Beverly Hills, California
Age range: 18 Years to 130 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (47 Sites)
Showing the first 25 of 47 sites.
- Research Site — Beverly Hills, California
- Research Site — La Jolla, California
- Research Site — Los Alamitos, California
- Research Site — Los Angeles, California
- Research Site — Santa Monica, California
- Research Site — Washington D.C., District of Columbia
- Research Site — Fort Lauderdale, Florida
- Research Site — Jupiter, Florida
- Research Site — Ocala, Florida
- Research Site — Orlando, Florida
- Research Site — St. Petersburg, Florida
- Research Site — Atlanta, Georgia
- Research Site — Atlanta, Georgia
- Research Site — Honolulu, Hawaii
- Research Site — Carterville, Illinois
- Research Site — Urbana, Illinois
- Research Site — Bethesda, Maryland
- Research Site — Jamaica Plain, Massachusetts
- Research Site — Saint Paul, Minnesota
- Research Site — Kansas City, Missouri
- Research Site — St Louis, Missouri
- Research Site — Billings, Montana
- Research Site — Grand Island, Nebraska
- Research Site — Lincoln, Nebraska
- Research Site — Albany, New York
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.