Reishi Mushroom Extract for Fatigue and/or Arthralgias/Myalgias in Patients With Breast Cancer on Aromatase Inhibitors (NCT06028022)
Reishi Mushroom Extract for Fatigue and/or Arthralgias in Patients With Breast Cancer on Aromatase Inhibitors: A Randomized Phase II MNCCTN Trial
🩺 Plain-English Summary (8th-Grade Level)
This phase II trial tests how well Reishi mushroom extract works in treating fatigue and/or joint/muscle pain (arthralgias/myalgias) in patients with breast cancer on aromatase inhibitors. Fatigue and arthralgias/myalgias are common symptoms in breast cancer patients taking aromatase inhibitors (AI). Given the long duration of AI treatment for some women (up to 10 years), these symptoms can significantly impact quality of life and premature discontinuation of AIs, a beneficial medication. Reishi mushrooms are among several medicinal mushrooms that have been used for hundreds of years, mainly in Asian countries, to help enhance the immune system, reduce stress, improve sleep, and lessen fatigue. Reishi mushroom extracts have not been studied explicitly for treatment-induced arthralgias/myalgias, but have been shown to improve quality of life, muscular strength, pain, and flexibility. Information from this study may help researchers determine the effect of Reishi mushroom extract on fatigue and arthralgias/myalgias in breast cancer patients receiving an AI.
Who can join: Review the eligibility criteria below.
Location: Mayo Clinic Health System in Albert Lea — Albert Lea, Minnesota
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (23 Sites)
- Mayo Clinic Health System in Albert Lea — Albert Lea, Minnesota
- Essentia Health Baxter Clinic — Baxter, Minnesota
- Sanford Joe Lueken Cancer Center — Bemidji, Minnesota
- Essentia Health Saint Joseph's Medical Center — Brainerd, Minnesota
- Essentia Health Deer River Clinic — Deer River, Minnesota
- Essentia Health Saint Mary's - Detroit Lakes Clinic — Detroit Lakes, Minnesota
- Essentia Health Cancer Center — Duluth, Minnesota
- Essentia Health Ely Clinic — Ely, Minnesota
- Essentia Health Fosston — Fosston, Minnesota
- Fairview Grand Itasca Clinic & Hospital — Grand Rapids, Minnesota
- Essentia Health Hibbing Clinic — Hibbing, Minnesota
- Fairview Range Medical Center — Hibbing, Minnesota
- Essentia Health International Falls Clinic — International Falls, Minnesota
- Mayo Clinic Health Systems-Mankato — Mankato, Minnesota
- MMCORC CentraCare Monticello Cancer Center — Monticello, Minnesota
- Essentia Health Moose Lake — Moose Lake, Minnesota
- Essentia Health Park Rapids — Park Rapids, Minnesota
- Fairview Northland Medical Center — Princeton, Minnesota
- Mayo Clinic in Rochester — Rochester, Minnesota
- Essentia Health Sandstone — Sandstone, Minnesota
- Sanford Thief River Falls Medical Center — Thief River Falls, Minnesota
- Essentia Health Virginia Clinic — Virginia, Minnesota
- Sanford Worthington Medical Center — Worthington, Minnesota
📞 Contact the Study Coordinator
Phone: (855) 776-0015
Email: mayocliniccancerstudies@mayo.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.