Study to Assess the Safety and Effectiveness of NMRA-335140-501 (NCT06029439)
Long-term Study to Assess the Safety and Effectiveness of NMRA-335140 in Participants With Major Depressive Disorder
🩺 Plain-English Summary (8th-Grade Level)
This is a 52-week open-label extension (OLE) study that will evaluate the safety, tolerability, and effectiveness of NMRA-335140 in participants with major depressive disorder (MDD). Participants who completed a parent study investigating the efficacy and safety of NMRA-335140 as a treatment for MDD (ie, NMRA-335140-301, NMRA-335140-302, or NMRA-335140-303), and complete the 6 weeks double-blind treatment, provide informed consent, and meet eligibility criteria, may enter this extension study.
Who can join: Review the eligibility criteria below.
Location: Neumora Investigator site — Huntsville, Alabama
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (178 Sites)
Showing the first 25 of 178 sites.
- Neumora Investigator site — Huntsville, Alabama
- Neumora Investigator Site — Phoenix, Arizona
- Neumora Investigator Site — Bentonville, Arkansas
- Neumora Investigator Site #1 — Little Rock, Arkansas
- Neumora Investigator site — Little Rock, Arkansas
- Neumora Investigator Site — Rogers, Arkansas
- Neumora Investigator site — Bellflower, California
- Neumora Investigator Site — Cerritos, California
- Neumora Investigator Site — Encino, California
- Neumora Investigator Site — Garden Grove, California
- Neumora Investigator Site — Glendale, California
- Neumora Investigator Site — Imperial, California
- Neumora Investigator Site — Irvine, California
- Neumora Investigator Site — Lafayette, California
- Neumora Investigator Site #1 — Long Beach, California
- Neumora Investigator site — Long Beach, California
- Neumora Investigator Site — Los Angeles, California
- Neumora Investigator Site — Newport Beach, California
- Neumora Investigator Site — Oceanside, California
- Neumora Investigator Site #1 — Orange, California
- Neumora Investigator Site — Orange, California
- Neumora Investigator Site — Riverside, California
- Neumora Investigator Site — San Diego, California
- Neumora Investigator Site — San Francisco, California
- Neumora Investigator Site — San Jose, California
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Major Depressive Disorder
- Fisher Wallace Neurostimulation & Depression Study — New York, New York
- Effects of Intravenous (IV) Citalopram Hydrochloride During Transcranial Magnetic Stimulation in Major Depressive Disorder (MDD) — Los Angeles, California
- Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression: Comparing One Versus Two Doses of Psilocybin — Toronto, Ontario
- Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder — West Haven, Connecticut
- Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humans — West Haven, Connecticut
Explore by condition: All Major Depressive Disorder clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.