Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis (NCT06034405)
🩺 Plain-English Summary (8th-Grade Level)
Primary objective: To identify older adults with transthyretin cardiac amyloidosis (ATTR-CA) early in the course of the illness, at a time when disease modifying therapies are most effective. The specific aims of this epidemiologic investigation include: 1. To identify subjects with previous lumbar spinal stenosis (LSS) Surgery who have evidence of transthyretin (TTR) amyloid deposits in spinal specimens and could be at risk for ATTR cardiac amyloidosis. 2. To evaluate for ATTR-CA among those with localized TTR in the spinal tissue. The study will also explore the following: 1. The prevalence of amyloid in lumbar spinal stenosis specimens by Congo Red staining. 2. The prevalence of TTR deposits among subjects with amyloid as determined by mass spectrometry. 3. Evaluation of a novel artificial intelligence technique for that can identify amyloid histologically with standard H\&E staining. 4. Difference in ATTR-CA prevalence between subjects with TTR and indeterminate amyloid deposits in subject's spine by myocardial uptake of technetium pyrophosphate scan (Tc99-PYP).
Who can join: Review the eligibility criteria below.
Location: Cedars-Sinai Medical Center — Beverly Hills, California
Age range: 50 Years
🧪 Interventions in This Study
- Tc99-PYP or Tc99-HDMP Scan (DIAGNOSTIC_TEST)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (6 Sites)
- Cedars-Sinai Medical Center — Beverly Hills, California
- Tufts Medical Center — Boston, Massachusetts
- Boston Medical Center — Boston, Massachusetts
- Mayo Clinic — Rochester, Minnesota
- Columbia University Irving Medical Center — New York, New York
- Cleveland Clinic — Cleveland, Ohio
📞 Contact the Study Coordinator
Phone: (212) 932-4537
Email: msm10@cumc.columbia.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Lumbar Spinal Stenosis
- A 5-year Superion™ IDS Clinical Outcomes Post-Approval Evaluation (SCOPE) — Carlsbad, California
- Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery — Chicago, Illinois
- REFINE Study: A Study In a Novel Interspinous Fusion Device In Subjects With Low Back Pain — Santa Rosa, California
- MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study — Athens, Alabama
- Lumbosacral Spinal Stenosis - Non-Invasive Postural Therapy for Older Adult Veterans — Baltimore, Maryland
- Study Comparing Local/ MAC Anesthesia in Lumbar Decompression — Redwood City, California
Explore by condition: All Lumbar Spinal Stenosis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.