Prediction and Prevention of Postoperative Mortality and Morbidity (NCT06042413)
Real-world and Innovative Multimodal Prediction and Prevention of Postoperative Mortality and Multi-morbidities
🩺 Plain-English Summary (8th-Grade Level)
This study will contribute to creating a prospective and automated preoperative risk assessment algorithm for predicting 30-day mortality, major adverse cardiac and cerebrovascular events (MACCE), and postoperative neurocognitive outcomes following elective cardiac and vascular surgery in older adults. It will evaluate associations between perioperative factors and longer-term neurocognitive outcomes, including postoperative neurocognitive disorder and dementia. In addition, this study will assess scalable, multimodal preoperative and intraoperative interventions to improve perioperative outcomes. This study will explore two main hypotheses: 1. Preoperative personalized prehabilitation with proactive cognitive and behavioral interventions will improve postoperative cognitive outcomes, morbidity, and mortality in high-risk elderly surgical patients. 2. Proactive bundled intraoperative interventions are superior to reactive standard of care in reducing postoperative cognitive outcomes, MACCE, and mortality. Expected Outcome: Improved EHR algorithm will have higher predictive accuracy for MACCE and mortality while predicting postoperative cognitive outcomes.
Who can join: Review the eligibility criteria below.
Location: UPMC Montefiore Hospital — Pittsburgh, Pennsylvania
Age range: 65 Years
🧪 Interventions in This Study
- Personalized CPC Prehabilitation (OTHER)
- Cognitive Training (BEHAVIORAL)
- Meditation (BEHAVIORAL)
- Daily Exercise (BEHAVIORAL)
- Enhanced Social Support (BEHAVIORAL)
- Proactive Bundle Interventions (OTHER)
- Pre-operative Standard of Care (PROCEDURE)
- Intra-operative Standard of Care (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (5 Sites)
- UPMC Montefiore Hospital — Pittsburgh, Pennsylvania
- UPMC Presbyterian Hospital — Pittsburgh, Pennsylvania
- UPMC Shadyside Hospital — Pittsburgh, Pennsylvania
- UPMC Mercy Hospital — Pittsburgh, Pennsylvania
- UPMC Passavant Hospital — Pittsburgh, Pennsylvania
📞 Contact the Study Coordinator
Phone: (412) 864-6779
Email: maslankaaa@upmc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.