MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk-Optimized Approach (NCT06050707)
🩺 Plain-English Summary (8th-Grade Level)
The proposed study is a phase II, single arm, open-label trial of MR-guided radiation therapy (RT) with risk stratified RT dose selection in patients with anal cancer. Based on previous data, a risk adaptive treatment approached is proposed in 4 groups: Low risk, standard risk, intermediate risk, and high risk. Human papillomavirus (HPV) DNA will be analyzed to identify novel biomarkers that predict chemoradiotherapy (CRT) response and toxicity.
Who can join: Review the eligibility criteria below.
Location: Allegheny Health Network — Pittsburgh, Pennsylvania
Age range: 18 Years
🧪 Interventions in This Study
- Radiotherapy - Low risk group (RADIATION)
- Radiotherapy - Standard risk group (RADIATION)
- Radiotherapy - Intermediate risk group (RADIATION)
- Radiotherapy - High risk group (RADIATION)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (5 Sites)
- Allegheny Health Network — Pittsburgh, Pennsylvania
- Medical College of Wisconsin Cancer Center — Milwaukee, Wisconsin
- Austin Health — Heidelberg, Victoria
- Princess Margaret Cancer Centre — Toronto, Ontario
- CHUM - Centre hospitalier de l'Université de Montréal — Montreal, Quebec
📞 Contact the Study Coordinator
Phone: (416) 946-2360
Email: ali.hosni@uhn.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Anal Squamous Cell Carcinoma
- Adaptive Radiation in Anal Cancer — New York, New York
Explore by condition: All Anal Squamous Cell Carcinoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.