MDMA-assisted Therapy for Fibromyalgia (NCT06066853)
Hyperscan Neuroimaging to Reveal the Brain Mechanisms Supporting Analgesia Following MDMA-assisted Therapy for Fibromyalgia
🩺 Plain-English Summary (8th-Grade Level)
Fibromyalgia is a debilitating chronic pain disorder. Based on prior research with MDMA, it can be hypothesized MDMA-assisted therapy in fibromyalgia patients may increase the range of positive emotions, interpersonal trust, and heighten the state of empathic rapport that can lead to an enhanced patient-clinician interaction and to initiate reattribution processes targeting dysfunctional thoughts towards pain. Therapeutic alliance, i.e. a positive patient-clinician relationship, is already acknowledged as an essential component for MDMA-assisted therapy. Despite its importance, the patient-clinician interaction and the neuroscience supporting patient/clinician therapeutic alliance has received almost no attention in MDMA research. The investigators will examine the potential therapeutic benefit of MDMA-assisted therapy for fibromyalgia. Additionally, this study will also target secondary objectives including the investigation of the clinical and physiological response (i.e. brain-to-brain concordance) supporting enhanced patient-clinician therapeutic alliance in fibromyalgia patients. The study includes two Experimental Sessions of therapy with MDMA combined with neuroimaging, along integrative therapy, baseline neuroimaging, and a 3 month follow up.
Who can join: Review the eligibility criteria below.
Location: Massachusetts General Hospital — Charlestown, Massachusetts
Age range: 21 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Massachusetts General Hospital — Charlestown, Massachusetts
📞 Contact the Study Coordinator
Phone: (617) 952-6483
Email: lgardiner1@mgb.org
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Fibromyalgia
- Virtual Specialty Clinic for Fibromyalgia Care — Covina, California
- A Study Of Virtual Reality Vs Sham VR On Fibromyalgia — Jacksonville, Florida
- Explosive Synchronization of Brain Network Activity in Chronic Pain — Ann Arbor, Michigan
- Microcurrent for Fibromyalgia — Nellis Air Force Base, Nevada
- Elucidating the Central Mechanisms of Action for Green Light Therapy in Managing Chronic Pain — Tucson, Arizona
- taVNS Treatment for Fibromyalgia — Charlestown, Massachusetts
Explore by condition: All Fibromyalgia clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.