LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia (NCT06073431)
Longitudinal Observational Trial to Uncover Subtypes of Cancer Cachexia
🩺 Plain-English Summary (8th-Grade Level)
This study evaluates cancer-related weight and muscle mass loss, symptoms, and physical function (cachexia) in patients undergoing treatment for colorectal, lung, or pancreatic cancer that cannot be removed by surgery (unresectable) or is stage IV. Patients with these cancer types are at risk for developing cancer cachexia (CC), which is defined as weight loss, muscle loss, and fat loss due to cancer. CC has been associated with reduced physical performance, impaired quality of life, and poorer survival. Many studies that have evaluated treatments for cancer-related weight and muscle loss have aimed to treat all patients with weight loss exactly the same and, unfortunately, have not been successful. Like different cancer types, weight and muscle loss related to cancer may have different causes in different individuals and the best treatment strategy for this condition may not be a one-size-fits-all approach. Information gathered from this study may help researchers develop new diagnostic criteria for CC and design better treatments and clinical trials for cancer-related weight and muscle loss in the future to improve the quality of life in patients with advanced colorectal, lung, or pancreatic cancer.
Who can join: Review the eligibility criteria below.
Location: Mercy Hospital Fort Smith — Fort Smith, Arkansas
Age range: 18 Years
🧪 Interventions in This Study
- Biospecimen Collection (PROCEDURE)
- Computed Tomography (PROCEDURE)
- Electronic Health Record Review (OTHER)
- Medical Device Usage and Evaluation (OTHER)
- Physical Performance Testing (OTHER)
- Positron Emission Tomography (PROCEDURE)
- Survey Administration (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (225 Sites)
Showing the first 25 of 225 sites.
- Mercy Hospital Fort Smith — Fort Smith, Arkansas
- Rocky Mountain Cancer Centers-Aurora — Aurora, Colorado
- Boulder Community Foothills Hospital — Boulder, Colorado
- Rocky Mountain Cancer Centers-Boulder — Boulder, Colorado
- Rocky Mountain Cancer Centers - Centennial — Centennial, Colorado
- The Women's Imaging Center — Denver, Colorado
- Colorado Blood Cancer Institute — Denver, Colorado
- Rocky Mountain Cancer Centers-Midtown — Denver, Colorado
- Rocky Mountain Cancer Centers-Rose — Denver, Colorado
- Rocky Mountain Cancer Centers - Swedish — Englewood, Colorado
- The Melanoma and Skin Cancer Institute — Englewood, Colorado
- Rocky Mountain Cancer Centers-Lakewood — Lakewood, Colorado
- Rocky Mountain Cancer Centers-Littleton — Littleton, Colorado
- Rocky Mountain Cancer Centers-Sky Ridge — Lone Tree, Colorado
- Rocky Mountain Cancer Centers-Thornton — Thornton, Colorado
- Beebe South Coastal Health Campus — Millville, Delaware
- Helen F Graham Cancer Center — Newark, Delaware
- Medical Oncology Hematology Consultants PA — Newark, Delaware
- Christiana Care Health System-Christiana Hospital — Newark, Delaware
- Beebe Health Campus — Rehoboth Beach, Delaware
- Christiana Care Health System-Wilmington Hospital — Wilmington, Delaware
- MedStar Georgetown University Hospital — Washington D.C., District of Columbia
- Northside Hospital — Atlanta, Georgia
- Northeast Georgia Medical Center Braselton — Braselton, Georgia
- John B Amos Cancer Center — Columbus, Georgia
📞 Contact the Study Coordinator
Phone: (800) 378-9373
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Advanced Colorectal Carcinoma
- Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestines — Duarte, California
- Danvatirsen and Durvalumab in Treating Patients With Advanced and Refractory Pancreatic, Non-Small Cell Lung Cancer, and Mismatch Repair Deficient Colorectal Cancer — Houston, Texas
- Understanding New Cachexia Subtypes Through Observational Epidemiological Research — Pleasanton, California
Explore by condition: All Advanced Colorectal Carcinoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.