A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (NCT06075667)
Efficacy, Safety, and Pharmacokinetics of Tirzepatide Once Weekly Versus Placebo in Adolescent Participants Who Have Obesity, or Are Overweight With Weight-Related Comorbidities: A Randomized, Double-Blind Trial (SURMOUNT-ADOLESCENTS)
🩺 Plain-English Summary (8th-Grade Level)
The main purpose of this study is to evaluate the safety and efficacy of tirzepatide in adolescents that have obesity or overweight with at least one weight-related comorbidity. The study will last approximately 90 weeks and may include up to 25 visits. Participants who have completed the primary 72-week GPHP study and have been off treatment for no more than 12 weeks (including the 4-week safety follow-up period), will have the opportunity to receive an additional 156 weeks of treatment with tirzepatide as well as continuing the lifestyle intervention.
Who can join: Review the eligibility criteria below.
Location: CenExel iResearch, LLC — Decatur, Georgia
Age range: 12 Years to 17 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (33 Sites)
Showing the first 25 of 33 sites.
- CenExel iResearch, LLC — Decatur, Georgia
- Solaris Clinical Research — Meridian, Idaho
- Cotton O'Neil Diabetes & Endocrinology — Topeka, Kansas
- Pennington Biomedical Research Center — Baton Rouge, Louisiana
- Barry J. Reiner, MD, LLC — Baltimore, Maryland
- M Health Fairview - Delaware Clinical Research Unit (DCRU) — Minneapolis, Minnesota
- Washington University School of Medicine — St Louis, Missouri
- Aventiv Research Inc — Columbus, Ohio
- PriMED Clinical Research — Dayton, Ohio
- Vanderbilt Health One Hundred Oaks — Nashville, Tennessee
- Alberta Diabetes Institute — Edmonton, Alberta
- The Wharton Medical Clinic Clinical Trials Inc — Hamilton, Ontario
- The Hospital for Sick Children — Toronto, Ontario
- CIUSSS- saguenay-Lac-Saint-Jean — Chicoutimi, Quebec
- ReFit Clinic — Olomouc, Olomouc Region
- Nemocnice AGEL Ostrava - Vitkovice a.s. — Ostrava, Ostrava Město
- Fakultni nemocnice v Motole — Prague, Praha 5
- Nemocnice Jihlava — Jihlava,
- Fakultni nemocnice Kralovske Vinohrady — Prague,
- Yitzhak Shamir Medical Center — Beer Yaacov, Central District
- Schneider Children's Medical Center — Petah Tikva, Central District
- Sheba Medical Center — Ramat Gan, Central District
- Shaare Zedek Medical Center — Jerusalem, Jerusalem
- Emek Medical Center — Afula, Northern District
- Rambam Health Care Campus — Haifa, Northern District
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.