Mechanistic Clinical Trial of PCSK9 Inhibition for AAA (NCT06081153)
A Randomized, Placebo-Controlled Mechanistic Clinical Trial of PCSK9 Inhibition With Evolocumab in Patients Undergoing Open Abdominal Aortic Aneurysm Repair
🩺 Plain-English Summary (8th-Grade Level)
The goal of this mechanistic clinical trial is to assess whether lowering the low-density lipoprotein cholesterol (LDL-C) levels in the blood with the injections of the medication evolocumab will have any effect on the tissue or cells of patients with abdominal aortic aneurysm (AAA). Researchers will compare participants receiving evolocumab injections to participants receiving placebo injections to see how the tissue and cells of the aorta are affected by changes in LDL-C levels.
Who can join: Review the eligibility criteria below.
Location: Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania
📞 Contact the Study Coordinator
Phone: (215) 615-1698
Email: damrauer@upenn.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Abdominal Aortic Aneurysm
- The Long-Term EVAR Assessment and Follow-Up (LEAF) Study for the AFX2 System — Lebanon, New Hampshire
- Post-Approval Study of the TREO Abdominal Stent-Graft System — Phoenix, Arizona
- GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis Post-Approval Study — Stanford, California
- First In Human Study for Small to Medium-sized Abdominal Aortic Aneurysm (AAA) — Randwick, New South Wales
- Global Fenestrated Anaconda Clinical STudy — Melbourne, Victoria
- The PREHAAAB Trial: Multimodal Prehabilitation for Patients Awaiting Open Abdominal Aortic Aneurysm Repair — Montreal, Quebec
Explore by condition: All Abdominal Aortic Aneurysm clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.