National Liver Cancer Screening Trial (NCT06084234)
🩺 Plain-English Summary (8th-Grade Level)
The National Liver Cancer Screening Trial is an adaptive randomized phase IV Trial comparing ultrasound-based versus biomarker-based screening in 5500 patients with cirrhosis from any etiology or patients with chronic hepatitis B infection. Eligible patients will be randomized in a 1:1 fashion to Arm A using semi-annual ultrasound and AFP-based screening or Arm B using semi-annual screening using GALAD alone. Randomization will be stratified by sex, enrolling site, Child Pugh class (A vs. B), and HCC etiology (viral vs. non-viral). Patients will be recruited from 15 sites (mix of tertiary care and large community health systems) over a 3-year period, and the primary endpoint of the phase IV trial, reduction in late-stage HCC, will be assessed after 5.5 years.
Who can join: Review the eligibility criteria below.
Location: University of Southern California — Los Angeles, California
Age range: 18 Years to 85 Years
🧪 Interventions in This Study
- GALAD (DIAGNOSTIC_TEST)
- Liver Ultrasound with or without AFP (DIAGNOSTIC_TEST)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (19 Sites)
- University of Southern California — Los Angeles, California
- Stanford University — Redwood City, California
- Kaiser Permanente — Roseville, California
- University of California, San Francisco — San Francisco, California
- Northwestern University — Chicago, Illinois
- Indiana University — Indianapolis, Indiana
- Massachusetts General Hospital — Boston, Massachusetts
- University of Michigan — Ann Arbor, Michigan
- Henry Ford Health System — Detroit, Michigan
- Hennepin Healthcare — Minneapolis, Minnesota
- University of Minnesota — Minneapolis, Minnesota
- The Feinstein Institutes, Northwell Health, Inc. — Manhasset, New York
- University of North Carolina — Chapel Hill, North Carolina
- Case Western Reserve University — Cleveland, Ohio
- The Cleveland Clinic — Cleveland, Ohio
- University of Pennsylvania — Philadelphia, Pennsylvania
- UT Southwestern Medical Center and Parkland Hospital — Dallas, Texas
- Baylor College of Medicine — Houston, Texas
- Virginia Commonwealth University — Richmond, Virginia
📞 Contact the Study Coordinator
Phone: (214) 645-8821
Email: Amit.Singal@UTSouthwestern.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Carcinoma, Hepatocellular
- Case-Control Study of the Glycotest™ HCC Panel Vs AFP for the Detection of Early-stage Hepatocellular Carcinoma — Los Angeles, California
- Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body. — Irvine, California
- Characterizing Disease Biology, Treatment and Toxicity in Older Adults With Hepatocellular Carcinoma — San Antonio, Texas
- Tislelizumab Consolidation After Liver-Directed Therapy for Hepatocellular Carcinoma — New Brunswick, New Jersey
- 90Y Transarterial Radioembolization Versus Microwave Ablation in Small Hepatocellular Carcinoma With Hypoalbuminemia — New Orleans, Louisiana
Explore by condition: All Carcinoma, Hepatocellular clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.