Randomized Phase II Trial of Targeted Radiation With no Castration for Mcrpc (NCT06084338)
Phase II Trial of Targeted Radiation With no Castration for Mcrpc
🩺 Plain-English Summary (8th-Grade Level)
This trial tests if the combination of comprehensive metastasis directed therapy delivered by a precision form of external beam radiotherapy (stereotactic ablative radiotherapy), combined with PSMA targeted radiopharmaceutical therapy and cessation of castration, and then followed by testosterone replacement, is an effective treatment for metastatic castration resistant prostate cancer. All patients will be treated with stereotactic ablative radiotherapy and PSMA targeted radiopharmaceutical therapy with cessation of castration. Half of patients are randomized to either receive, or not receive, subsequent testosterone replacement.
Who can join: Review the eligibility criteria below.
Location: VA Greater Los Angeles Healthcare System, West Los Angeles, CA — West Los Angeles, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (4 Sites)
- VA Greater Los Angeles Healthcare System, West Los Angeles, CA — West Los Angeles, California
- Edward Hines Jr. VA Hospital, Hines, IL — Hines, Illinois
- Richard L. Roudebush VA Medical Center, Indianapolis, IN — Indianapolis, Indiana
- VA Ann Arbor Healthcare System, Ann Arbor, MI — Ann Arbor, Michigan
📞 Contact the Study Coordinator
Phone: (310) 478-3711
Email: nicholas.nickols@va.gov
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.