A Study of JNJ-87189401 Combined With JNJ-78278343 for Advanced Prostate Cancer (NCT06095089)
A Phase 1 Study of JNJ-87189401 (PSMA-CD28 Bispecific Antibody) Combined With JNJ-78278343 (KLK2-CD3 Bispecific Antibody) for Advanced Prostate Cancer
🩺 Plain-English Summary (8th-Grade Level)
The purpose of Parts 1, 2A, and 2B of the study is to determine the recommended regimen for Phase 2 (RP2Rs) of combination of JNJ-87189401 with JNJ-78278343 and the purpose of Part 2C of this study is to determine how safe the RP2R(s) of the combination of JNJ-87189401 and JNJ-78278343 is, with or without apalutamide. Part 3 of this study evaluates the safety of the triplet combination of JNJ-87189401 and JNJ-78278343 with standard of care (SOC) lutetium Lu-177 vipivotide tetraxetan. Part 4 of this study further evaluates the safety of the triplet combination of JNJ-87189401 and JNJ-78278343 with JNJ-101556143 in participants with advanced prostate cancer.
Who can join: Review the eligibility criteria below.
Location: University of Colorado Anschutz Medical Campus — Aurora, Colorado
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (19 Sites)
- University of Colorado Anschutz Medical Campus — Aurora, Colorado
- Emory University Winship Cancer Institute — Atlanta, Georgia
- University Of Minnesota — Minneapolis, Minnesota
- START New Jersey — East Brunswick, New Jersey
- Herbert Irving Comprehensive Cancer Center Columbia University Medical Center — New York, New York
- Atrium Health Levine Cancer Institute — Charlotte, North Carolina
- Oregon Health And Science University — Portland, Oregon
- Sidney Kimmel Cancer Center - Jefferson Health — Philadelphia, Pennsylvania
- Tennessee Oncology — Nashville, Tennessee
- MD Anderson Cancer Center — Houston, Texas
- South Texas Accelerated Research Therapeutics, LLC (START) — San Antonio, Texas
- Swedish Medical Center — Seattle, Washington
- Greenslopes Private Hospital — Greenslopes,
- Peter MacCallum Cancer Centre — Melbourne,
- The First Affiliated Hospital of Wenzhou Medical University — Wenzhou,
- Institut Bergonie — Bordeaux,
- Centre Leon Berard — Lyon,
- Institut Gustave Roussy — Villejuif,
- The Cancer Institute Hospital of JFCR — Tokyo,
📞 Contact the Study Coordinator
Phone: (844) 434-4210
Email: Participate-In-This-Study1@its.jnj.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.