Pulsed Field Ablation (PFA) vs Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation (NCT06096337)
A Prospective Randomized Multicenter Global Study Comparing Pulsed Field Ablation (PFA) Versus Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to establish the safety and effectiveness of pulsed field ablation as a first-line ablation treatment for subjects with persistent atrial fibrillation as compared to subjects who received an initial treatment with anti-arrhythmic drugs.
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (61 Sites)
Showing the first 25 of 61 sites.
- University of Alabama at Birmingham — Birmingham, Alabama
- Banner University Medical Center Phoenix — Phoenix, Arizona
- Phoenix Cardiovascular Research Group — Phoenix, Arizona
- Arrhythmia Research Group — Jonesboro, Arkansas
- Scripps Memorial Hosptial — La Jolla, California
- Stanford University Medical Center — Palo Alto, California
- Cardiology Associates Medical Group, Inc — Ventura, California
- HCA Florida Mercy Hospital — Miami, Florida
- Sarasota Memorial Hospital — Sarasota, Florida
- Tallahassee Memorial Hospital — Tallahassee, Florida
- St. Joseph's Hospital — Tampa, Florida
- Emory University Hospital — Atlanta, Georgia
- Memorial Health University Medical Center — Savannah, Georgia
- St. John's Hospital — Springfield, Illinois
- Community Heart and Vascular Hospital — Indianapolis, Indiana
- Mercy Hospital Medical Center-Hospital — West Des Moines, Iowa
- Baptist Health Lexington — Lexington, Kentucky
- Johns Hopkins Hospital — Baltimore, Maryland
- Brigham and Women's Hospital — Boston, Massachusetts
- Southcoast Physicians Group — Fall River, Massachusetts
- University of Michigan Hospitals — Ann Arbor, Michigan
- Corewell Health — Grand Rapids, Michigan
- Mayo Clinic Foundation-Hospital — Rochester, Minnesota
- Catholic Medical Center — Manchester, New Hampshire
- Valley Hospital — Paramus, New Jersey
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Persistent Atrial Fibrillation
- Pragmatic Evaluation of a Pentaspline Pulsed Field Ablation System to Treat Atrial Fibrillation and Related Arrhythmias — Jonesboro, Arkansas
- SPHERE Per-AF Post-Approval Study — Birmingham, Alabama
- Correlation of the Arrhythmia Mechanism and Substrate to Ablate Persistent Atrial Fibrillation Study — Ottawa, Ontario
- STOP Persistent AF PAS — Hartford, Connecticut
- REPRESENT-PF Registry — New York, New York
Explore by condition: All Persistent Atrial Fibrillation clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.