🏛️ Verified NIH Record • Updated 2026-03-30
Effect of Naltrexone Hydrochloride ER and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on Major Adverse Cardiovascular Events (MACE) (NCT06098079)
A Phase IV Study to Assess the Effect of Naltrexone Hydrochloride Extended Release (ER) and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on the Occurrence of Major Adverse Cardiovascular Events
🔵 Active, Not Recruiting Phase4 💊 Investigational Drug / Biologic Sponsor: Currax Pharmaceuticals
🩺 Plain-English Summary (8th-Grade Level)
A randomized, double-blinded, placebo controlled study intended to capture cardiovascular outcomes during real-world use of naltrexone/bupropion (NB).
Who can join: Review the eligibility criteria below.
Location: TrialMed Birmingham (DRS) — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (140 Sites)
Showing the first 25 of 140 sites.
- TrialMed Birmingham (DRS) — Birmingham, Alabama
- Accel Research Sites Network — Birmingham, Alabama
- Cullman Clinical Trials — Cullman, Alabama
- AMR Mobile — Mobile, Alabama
- Velocity Clinical Research, Mobile — Mobile, Alabama
- Sun City Research — Glendale, Arizona
- Cardiovascular Consultants/NextStage Clinical Research — Glendale, Arizona
- Desert Clinical Research — Mesa, Arizona
- Velocity Clinical Research, Phoenix — Phoenix, Arizona
- Fiel Family & Sports Medicine CCT Research — Tempe, Arizona
- Synexus Clinical Research US; Inc. — Tucson, Arizona
- Velocity Clinical Research, Gardena — Anderson, California
- Velocity Clinical Research — Chula Vista, California
- Velocity Clinical Research, Huntington Park — Huntington Park, California
- Velocity Clinical Research, San Diego — La Mesa, California
- Chemidox Clinical Trials Inc. — Lancaster, California
- Long Beach Clinical Trials — Long Beach, California
- Velocity Clinical Research — Los Angeles, California
- Valley Vitality Ventures — Manteca, California
- National Institute of Clinical Research, Inc. — Pomona, California
- Velocity Clinical Research, San Bernardino — San Bernardino, California
- Velocity Clinical Research at Coastal Heart Medical Group — Santa Ana, California
- Velocity Clinical Research of Santa Ana — Santa Ana, California
- Velocity Clinical Research, Van Nuys — Van Nuys, California
- Providere Research — West Covina, California
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.