Testosterone and Neural Function (NCT06130449)
The Role of Androgens in Neurophysiological and Autonomic Function in Male Veterans With Spinal Cord Injury
🩺 Plain-English Summary (8th-Grade Level)
Spinal cord injury (SCI) disrupts the nerves controlling movement, along with those that regulate functions like heart rate and blood pressure (known as the autonomic nervous system, or ANS). Testosterone (T) plays a significant role in brain health and ANS reflex function in non-neurologically impaired men. However, little is known about the relationships between T, nerve function, and ANS dysfunction after SCI. Interestingly, up to 60% of men with SCI exhibit persistently low T concentrations, which may worsen nerve and ANS dysfunction. In uninjured eugonadal people (normal physiologic range of serum T concentrations), a single pharmacologic dose of intranasal T has been shown to quickly improve nerve function, but no study has evaluated if T administration alters nerve and ANS function in men with SCI. Herein, the investigators will conduct the first study to test how a single dose of intranasal T impacts motor and ANS function in this population.
Who can join: Review the eligibility criteria below.
Location: James J. Peters VA Medical Center, Bronx, NY — The Bronx, New York
Age range: 18 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- James J. Peters VA Medical Center, Bronx, NY — The Bronx, New York
📞 Contact the Study Coordinator
Phone: (718) 584-9000
Email: Jacob.Goldsmith@va.gov
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Spinal Cord Injury
- AIH-induced Walking Recovery After Subacute SCI — Atlanta, Georgia
- C-Brace II Spinal Cord Injury — Chicago, Illinois
- Autonomic Effects of Stimulation in SCI — The Bronx, New York
- Time Restricted Eating to Mitigate Obesity in Veterans With Spinal Cord Injury — Syracuse, New York
- Implanted Myoelectric Control for Restoration of Hand Function in Spinal Cord Injury — Cleveland, Ohio
- Electrical Stimulation for Continence After Spinal Cord Injury — Palo Alto, California
Explore by condition: All Spinal Cord Injury clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.