Efficacy of M640 in Acute Lumbosacral Musculoskeletal Conditions. (NCT06157177)
Efficacy of Modified Release Metaxalone 640 mg in Acute Lumbosacral Musculoskeletal Conditions With Spinal Stenosis and Sciatica
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is to learn if a modification to metaxalone 640 mg can reduce low back and leg pain. The participants will be 18 to 80 years old, healthy with newly occurring back or leg pain. The main question aims to compare a group taking active treatment and a group taking a look-alike substance containing no active treatment. All participants will answer questions on Day 1, before treatment, and on 7-day after treatment, about: * Amount and quality of pain * Interference with physical activity * Interference with sleep
Who can join: Review the eligibility criteria below.
Location: East Alabama Arthritis Center — Auburn, Alabama
Age range: 18 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (24 Sites)
- East Alabama Arthritis Center — Auburn, Alabama
- Sean Wollaston, MD — Valley Village, California
- Arthritis and Osteoporosis Center — Aventura, Florida
- William Sunshine, MD — Boca Raton, Florida
- Robert Levin, MD — Clearwater, Florida
- 5. CZ Rheumatology — Coral Springs, Florida
- 4. Palm Beach Rheumatology and Wellness — Jupiter, Florida
- Family Arthritis Center — Loxahatchee Groves, Florida
- Arthritis and Rheumatology Center of South Florida — Margate, Florida
- Arthritis and Osteoporosis Treatment and ResearchCenter — Miami, Florida
- CZ Rheumatology — Miami Beach, Florida
- Bay Area Rheumatology — Oldsmar, Florida
- Arthritis and Rheumatic Care Center — South Miami, Florida
- Arthritis Research and Treatment Center — Stockbridge, Georgia
- Arthritis and Rheumatology Center of MI — Sterling Heights, Michigan
- Jayashree Sinha, MD 1 — Clovis, New Mexico
- Carolina Rheumatology — Fayetteville, North Carolina
- Ohio Arthritis and Osteoporosis Center of Southwest Ohio — Springboro, Ohio
- Cumberland Rheumatology — Crossville, Tennessee
- Heritage Rheumatology & Arthritis Care — Colleyville, Texas
- Integrative Rheumatology of South Texas — Harlingen, Texas
- Southwest Research Group — Mesquite, Texas
- DFW Rheumatology — Red Oak, Texas
- Northern Virginia Center for Arthritis — Annandale, Virginia
📞 Contact the Study Coordinator
Phone: (205) 202-0739
Email: simi@illumination.health
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Sciatica Acute
- Comparing Ultrasound-Guided Transgluteal Nerve Block to Standard Care — San Francisco, California
Explore by condition: All Sciatica Acute clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.