🏛️ Verified NIH Record • Updated 2026-04-28

PHESGO Maintenance After T-DXd Short Induction for HER2+ Unresectable Locally Recurrent or Metastatic Breast Cancer (NCT06172127)

A Multicenter, Open-Label, Single-Arm, Phase II Trial Exploring the Maintenance of Trastuzumab and Pertuzumab Following Trastuzumab Deruxtecan as Induction Treatment for HER2+ Unresectable Locally Recurrent or Metastatic Breast Cancer

🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: MedSIR

🩺 Plain-English Summary (8th-Grade Level)

DEMETHER is a phase II trial exploring the maintenance of trastuzumab and pertuzumab fixed dose combination (FDC) for subcutaneous administration (SC, PHESGO) following trastuzumab deruxtecan (T-DXd) as induction treatment for HER2-positive unresectable locally recurrent or metastatic breast cancer (MBC) patients.

Who can join: Review the eligibility criteria below.

Location: Dana-Farber Cancer Institute — Boston, Massachusetts

Age range: 18 Years

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (36 Sites)

Showing the first 25 of 36 sites.

  • Dana-Farber Cancer Institute — Boston, Massachusetts
  • Northwell Health — New York, New York
  • Institute Paoli Calmettes — Marseille,
  • Hopital Europeen Georges Pompidou — Paris,
  • Hôpital Tenon AP-HP — Paris,
  • Marienhospital Bottrop GmbH Klinik für Gynäkologie und Geburtshilfe — Bottrop,
  • Kliniken Essen Mitte — Essen,
  • Mammazentrum HH — Hamburg,
  • Klinikum der Universität München — München,
  • Humanitas Gavazzeni — Bergamo,
  • Instituto Europeo di Oncologia — Milan,
  • University Hospital Maggiore della Carita — Novara,
  • Fondazione Policlinico Universitario Agostino Gemelli — Roma,
  • Hospital Universitario Virgen del Rocío — Seville, Sevilla
  • Hospital del Vinalopó — Alicante,
  • Hospital General Universitario Dr. Balmis (Alicante) — Alicante,
  • Hospital Clínic i Provincial de Barcelona — Barcelona,
  • Hospital Universitari Dexeus — Barcelona,
  • Institut Català d' Oncologia L'Hospitalet (ICO) — Barcelona,
  • Hospital Universitario de Basurto — Bilbao,
  • Hospital Provincial de Castellón — Castellon,
  • Hospital Universitario Reina Sofía — Córdoba,
  • Hospital Universitario Clínico San Cecilio de Granada — Granada,
  • Hospital Universitario de León — León,
  • Hospital Beata María Ana — Madrid,

📞 Contact the Study Coordinator

Phone: (877) 338-7425

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗