PHESGO Maintenance After T-DXd Short Induction for HER2+ Unresectable Locally Recurrent or Metastatic Breast Cancer (NCT06172127)
A Multicenter, Open-Label, Single-Arm, Phase II Trial Exploring the Maintenance of Trastuzumab and Pertuzumab Following Trastuzumab Deruxtecan as Induction Treatment for HER2+ Unresectable Locally Recurrent or Metastatic Breast Cancer
🩺 Plain-English Summary (8th-Grade Level)
DEMETHER is a phase II trial exploring the maintenance of trastuzumab and pertuzumab fixed dose combination (FDC) for subcutaneous administration (SC, PHESGO) following trastuzumab deruxtecan (T-DXd) as induction treatment for HER2-positive unresectable locally recurrent or metastatic breast cancer (MBC) patients.
Who can join: Review the eligibility criteria below.
Location: Dana-Farber Cancer Institute — Boston, Massachusetts
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (36 Sites)
Showing the first 25 of 36 sites.
- Dana-Farber Cancer Institute — Boston, Massachusetts
- Northwell Health — New York, New York
- Institute Paoli Calmettes — Marseille,
- Hopital Europeen Georges Pompidou — Paris,
- Hôpital Tenon AP-HP — Paris,
- Marienhospital Bottrop GmbH Klinik für Gynäkologie und Geburtshilfe — Bottrop,
- Kliniken Essen Mitte — Essen,
- Mammazentrum HH — Hamburg,
- Klinikum der Universität München — München,
- Humanitas Gavazzeni — Bergamo,
- Instituto Europeo di Oncologia — Milan,
- University Hospital Maggiore della Carita — Novara,
- Fondazione Policlinico Universitario Agostino Gemelli — Roma,
- Hospital Universitario Virgen del Rocío — Seville, Sevilla
- Hospital del Vinalopó — Alicante,
- Hospital General Universitario Dr. Balmis (Alicante) — Alicante,
- Hospital Clínic i Provincial de Barcelona — Barcelona,
- Hospital Universitari Dexeus — Barcelona,
- Institut Català d' Oncologia L'Hospitalet (ICO) — Barcelona,
- Hospital Universitario de Basurto — Bilbao,
- Hospital Provincial de Castellón — Castellon,
- Hospital Universitario Reina Sofía — Córdoba,
- Hospital Universitario Clínico San Cecilio de Granada — Granada,
- Hospital Universitario de León — León,
- Hospital Beata María Ana — Madrid,
📞 Contact the Study Coordinator
Phone: (877) 338-7425
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in HER2-positive Breast Cancer
- Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease — Tampa, Florida
- Neoadjuvant Her2-targeted Therapy and Immunotherapy With Pembrolizumab [IIT2018-04-MCARTHUR-NEOHP] — Los Angeles, California
- ELVN-002 With Trastuzumab +/- Chemotherapy in HER2+ Solid Tumors, Colorectal and Breast Cancer — Plantation, Florida
- A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer — Mobile, Alabama
- A Single Arm Phase II Study of ADjuvant Endocrine Therapy, Pertuzumab, and Trastuzumab for Patients With Anatomic Stage I Hormone Receptor-positive, HER2-positive Breast Cancer — Stamford, Connecticut
Explore by condition: All HER2-positive Breast Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.