Evaluation of A Clinical Diagnostic Test for CRDS (NCT06188689)
Evaluation of a Clinical Diagnostic Test for Calcium Release Deficiency Syndrome: The DIAGNOSE CRDS Study
🩺 Plain-English Summary (8th-Grade Level)
Calcium Release Deficiency Syndrome (CRDS) is a novel inherited arrhythmia syndrome secondary to RyR2 loss-of-function that confers a risk of sudden cardiac death. Diagnosis of CRDS presently requires cellular-based in vitro confirmation that an RyR2 variant causes loss-of-function. We hypothesize that CRDS can be diagnosed clinically through evaluation of the repolarization response to brief tachycardia, mediated by cardiac pacing, and a subsequent pause.
Who can join: Review the eligibility criteria below.
Location: University of California — San Francisco, California
🧪 Interventions in This Study
- Pacing (DIAGNOSTIC_TEST)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (20 Sites)
- University of California — San Francisco, California
- Boston Children's Hospital — Boston, Massachusetts
- Mayo Clinic — Rochester, Minnesota
- University of Washington — Seattle, Washington
- Antwerp University Hospital — Edegem, Antwerp
- Universitair Ziekenhuis Brussel — Brussels,
- University of Calgary — Calgary, Alberta
- Alberta Health Services — Edmonton, Alberta
- Children's & Women's Health Centre of British Columbia — Vancouver, British Columbia
- The University of British Columbia — Vancouver, British Columbia
- Hamilton General Hospital — Hamilton, Ontario
- London Health Sciences Centre - University Hospital — London, Ontario
- Ottawa Heart Institute — Ottawa, Ontario
- Toronto General Hospital — Toronto, Ontario
- Montréal Heart Institute — Montreal, Quebec
- Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval — Québec, Quebec
- Aarhus University Hospital — Aarhus,
- CHU de Bordeaux — Bordeaux, New Aquitaine
- Shaare Zedek Medical Center — Jerusalem,
- Oxford University Hospitals — Oxford, Oxfordshire
📞 Contact the Study Coordinator
Phone: (905) 297-3479
Email: jason.roberts@phri.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Calcium Release Deficiency Syndrome (CRDS) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.