Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer (NCT06208657)

🧪 Interventions in This Study

• Paxalisib (DRUG)
• Opdualag (DRUG)
• Irinotecan (drug) (DRUG)
• Temozolomide (TMZ) (DRUG)

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (14 Sites)

• John Hunter Children's Hospital — Newcastle, New South Wales
• Sydney Children's Hospital, Randwick — Sydney, New South Wales
• The Children's Hospital at Westmead — Sydney, New South Wales
• Queensland Children's Hospital — Brisbane, Queensland
• Women's and Children's Hospital — Adelaide, South Australia
• Royal Hobart Hospital — Hobart, Tasmania
• Monash Children's Hospital — Melbourne, Victoria
• The Royal Children's Hospital — Melbourne, Victoria
• Perth Children's Hospital — Perth, Western Australia
• Stollery Children's Hospital — Edmonton,
• CHU Sainte Justine — Montreal,
• Children's Hospital of Eastern Ontario — Ottawa,
• The Hospital for Sick Children — Toronto,
• BC Children's Hospital — Vancouver,

📞 Contact the Study Coordinator

Phone: +61 2 9382 1730

Email: SCHN-OPTIMISE@health.nsw.gov.au

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

• 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
• Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
• Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

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💡 How to Participate

1. Check the checklist above to see if you may qualify.
2. Contact the study coordinator using the phone/email above.
3. Ask about the visit schedule, what is covered at no cost, and any travel support.
4. Confirm with your own doctor before making a decision.