Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use Disorder (NCT06233799)
Randomized, Placebo-Controlled, Multi-Site Trial of Extended-Release Naltrexone Injection/Bupropion XL Tablets in the Treatment of Methamphetamine Use Disorder
🩺 Plain-English Summary (8th-Grade Level)
The primary objective of this study is to evaluate the efficacy of extended release naltrexone plus bupropion XL (XR-NTX/BUP-XL) compared to matched injectable and oral placebo (iPLB/oPLB) in reducing methamphetamine (MA) use in individuals with moderate or severe methamphetamine use disorder (MUD) seeking to stop or reduce MA use.
Who can join: Review the eligibility criteria below.
Location: University of Arkansas for Medical Sciences — Little Rock, Arkansas
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (11 Sites)
- University of Arkansas for Medical Sciences — Little Rock, Arkansas
- University of California Los Angeles — Los Angeles, California
- University of California at San Diego — San Diego, California
- Indiana University — Indianapolis, Indiana
- University of Kansas Medical Center — Kansas City, Kansas
- University of Minnesota — Minneapolis, Minnesota
- CODA — Portland, Oregon
- MUSC/BHS — Pickens, South Carolina
- University of Tennessee — Memphis, Tennessee
- University of Texas Southwestern Medical Center — Dallas, Texas
- University of Virginia — Charlottesville, Virginia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Methamphetamine-dependence
- Glutide for Ending Methamphetamine — San Francisco, California
Explore by condition: All Methamphetamine-dependence clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.