Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation (NCT06252649)
Phase 3 Multicenter, Randomized, Open-label, Active-controlled Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb for Treatment-naïve Subjects With Metastatic Colorectal Cancer With KRAS p.G12C Mutation (CodeBreaK 301)
🩺 Plain-English Summary (8th-Grade Level)
The aim of this study is to compare progression free survival (PFS) in treatment-naïve participants with KRAS p.G12C mutated metastatic colorectal cancer (mCRC) receiving sotorasib, panitumumab and FOLFIRI vs FOLFIRI with or without bevacizumab-awwb.
Who can join: Review the eligibility criteria below.
Location: Ironwood Cancer and Research Centers Scottsdale — Chandler, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (291 Sites)
Showing the first 25 of 291 sites.
- Ironwood Cancer and Research Centers Scottsdale — Chandler, Arizona
- Providence Saint Jude Medical Center — Fullerton, California
- City of Hope National Medical Center — Long Beach, California
- Cancer and Blood Research Center, LLC — Los Alamitos, California
- California Research Institute — Los Angeles, California
- Norwalk Hospital — Norwalk, Connecticut
- Cancer Specialists of North Florida - Southpoint — Jacksonville, Florida
- D and H Cancer Research Center — Margate, Florida
- Mid Florida Hematology and Oncology Centers PA — Orange City, Florida
- Boca Raton Clinical Research Medical Center Inc — Plantation, Florida
- Georgia Cancer Specialists — Atlanta, Georgia
- Insight Research Institute — Chicago, Illinois
- Hope and Healing Cancer Services — Hinsdale, Illinois
- Orchard Healthcare Research Inc — Skokie, Illinois
- Pikeville Medical Center — Pikeville, Kentucky
- Henry Ford Health System — Detroit, Michigan
- Cancer and Hematology Centers of Western Michigan — Grand Rapids, Michigan
- Saint Louis Cancer Care West County — Bridgeton, Missouri
- Minniti Center for Medical Oncology and Hematology — Mickleton, New Jersey
- Duke Cancer Center — Durham, North Carolina
- FirstHealth Cancer Center — Pinehurst, North Carolina
- Thomas Jefferson University — Philadelphia, Pennsylvania
- Carolina Blood and Cancer Care — Rock Hill, South Carolina
- Tennessee Oncology PLLC - Chattanooga — Nashville, Tennessee
- Tennessee Oncology, PLLC — Nashville, Tennessee
📞 Contact the Study Coordinator
Phone: (866) 572-6436
Email: medinfo@amgen.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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Explore by condition: All Metastatic Colorectal Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.