🏛️ Verified NIH Record • Updated 2025-11-18
An Extension Study to Evaluate the Long-Term Safety and Efficacy of Votoplam in Participants With Huntington's Disease (HD) (NCT06254482)
A Phase 2b, Double-Blind, Randomized Extension Study to Evaluate the Long-Term Safety and Efficacy of Votoplam in Participants With Huntington's Disease
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Novartis Pharmaceuticals
🩺 Plain-English Summary (8th-Grade Level)
The primary goal of this study is to evaluate the long-term safety and pharmacodynamic effects of votoplam in participants with HD.
Who can join: Review the eligibility criteria below.
Location: Novartis Investigative Site — Clayton
Age range: 25 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (24 Sites)
- Novartis Investigative Site — Clayton,
- Novartis Investigative Site — Westmead,
- Novartis Investigative Site — Innsbruck,
- Novartis Investigative Site — Ottawa,
- Novartis Investigative Site — Angers,
- Novartis Investigative Site — Marseille,
- Novartis Investigative Site — Paris,
- Novartis Investigative Site — Berlin,
- Novartis Investigative Site — Bochum,
- Novartis Investigative Site — Münster,
- Novartis Investigative Site — Ulm,
- Novartis Investigative Site — Bologna,
- Novartis Investigative Site — Milan,
- Novartis Investigative Site — San Giovanni Rotondo,
- Novartis Investigative Site — Leiden,
- Novartis Investigative Site — Christchurch,
- Novartis Investigative Site — Barakaldo,
- Novartis Investigative Site — Barcelona,
- Novartis Investigative Site — Burgos,
- Novartis Investigative Site — Madrid,
- Novartis Investigative Site — Birmingham,
- Novartis Investigative Site — Cardiff,
- Novartis Investigative Site — London,
- Novartis Investigative Site — Manchester,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Huntington Disease
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- Impact of Deutetrabenazine on Functional Speech and Gait Dynamics in Huntington Disease — Nashville, Tennessee
- GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease — Birmingham, Alabama
- Modification of Threat Interpretation Bias to Reduce Anxiety in Neurodegenerative Movement Disorders (Aim 3) — Charlottesville, Virginia
- Multi-Modal Digital Monitoring of Disease Symptoms Huntington's Disease — Rochester, New York
Explore by condition: All Huntington Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.