A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis (NCT06254950)
A Phase 2, Multicenter, Randomized, Placebo-Controlled, Double-Blind Induction Study to Evaluate the Efficacy and Safety of Oral TAK-279 in Subjects With Moderately to Severely Active Ulcerative Colitis
🩺 Plain-English Summary (8th-Grade Level)
The main aim of this study is to learn if TAK-279 reduces bowel inflammation and symptoms compared to placebo. Another aim is to compare any medical problems that participants have when they take TAK-279 or placebo and how well the participants tolerate any problems. The participants will take capsules of either TAK-279 or placebo for up to 3 months (12 weeks). Then all the participants will receive TAK-279 for the rest of the treatment part of the study (1 year or 52 weeks). During the study, participants will visit their study clinic several times.
Who can join: Review the eligibility criteria below.
Location: GastroIntestinal BioSciences — Los Angeles, California
Age range: 18 Years to 75 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (141 Sites)
Showing the first 25 of 141 sites.
- GastroIntestinal BioSciences — Los Angeles, California
- United Medical Doctors — Murrieta, California
- West Central Gastroenterology, LLP, d/b/a/ Gastro Florida — Clearwater, Florida
- Auzmer Research — Lakeland, Florida
- GI PROS, Inc. — Naples, Florida
- USF Health Morsani Center for Advanced Healthcare — Tampa, Florida
- Emory University Hospital, The Emory Clinic — Atlanta, Georgia
- Atlanta Center For Gastroenterology, P.C. — Decatur, Georgia
- University Of Louisville — Louisville, Kentucky
- Woodholme Gastroenterology Associates — Glen Burnie, Maryland
- Las Vegas Medical Research — Las Vegas, Nevada
- University Gastroenterology — Providence, Rhode Island
- Gastroenterology Associates, PA — Greenville, South Carolina
- Novel Research, LLC — Bellaire, Texas
- Tyler Research Institute, LLC — Tyler, Texas
- University of Washington Medical Center — Seattle, Washington
- Concord Repatriation General Hospital — Sydney, New South Wales
- Mater Cancer Care Centre-Mater Health Services — South Brisbane, Queensland
- Flinders Medical Centre — Bedford Park, South Australia
- The Queen Elizabeth Hospital — Woodville, South Australia
- The Alfred Hospital — Melbourne, Victoria
- Western Health/Footscray Hospital — Melbourne, Victoria
- Sir Charles Gairdner Hospital Lung Institute Of Western Australia — Nedlands, Western Australia
- Royal Perth Hospital — Perth, Western Australia
- Harry Perkins Medical Research Institute Fiona Stanley Hospital — Murdoch,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Ulcerative Colitis
- A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001) — Dothan, Alabama
- Pharmacokinetics of IFX and TNF Concentrations in Serum, Stool, and Colonic Mucosa in Acute Severe Ulcerative Colitis — San Diego, California
- A Study to Evaluate the Safety of Ozanimod Exposure During Pregnancy in Women With Ulcerative Colitis and Their Infants — Eden Prairie, Minnesota
- CP101 for the Treatment of Ulcerative Colitis — Boston, Massachusetts
- Angiographic Delivery of AD-MSC for Ulcerative Colitis — Rochester, Minnesota
Explore by condition: All Ulcerative Colitis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.