๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2025-07-21

Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease (NCT06268886)

A Randomized, Double-blind, Placebo-controlled, Global Proof-of-concept Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986446, an Anti-MTBR Tau Monoclonal Antibody, in Participants With Early Alzheimer's Disease (TargetTau-1)

๐Ÿ”ต Active, Not Recruiting Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Bristol-Myers Squibb

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The purpose of this study is to assess the effectiveness, safety, and tolerability of BMS-986446 an Anti-MTBR Tau Monoclonal Antibody in participants with Early Alzheimer's Disease.

Who can join: Review the eligibility criteria below.

Location: Local Institution - 0068 โ€” Chandler, Arizona

Age range: 50 Years to 80 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (176 Sites)

Showing the first 25 of 176 sites.

  • Local Institution - 0068 โ€” Chandler, Arizona
  • Local Institution - 0102 โ€” Gilbert, Arizona
  • Local Institution - 0019 โ€” Phoenix, Arizona
  • Local Institution - 0018 โ€” Scottsdale, Arizona
  • Local Institution - 0026 โ€” Scottsdale, Arizona
  • Local Institution - 0077 โ€” Tucson, Arizona
  • Local Institution - 0038 โ€” Tucson, Arizona
  • Local Institution - 0164 โ€” Encino, California
  • Local Institution - 0139 โ€” Fullerton, California
  • Local Institution - 0191 โ€” Irvine, California
  • Local Institution - 0234 โ€” Long Beach, California
  • Local Institution - 0142 โ€” Los Alamitos, California
  • Local Institution - 0037 โ€” Napa, California
  • Local Institution - 0209 โ€” Sacramento, California
  • Local Institution - 0052 โ€” San Francisco, California
  • Local Institution - 0137 โ€” Santa Ana, California
  • Local Institution - 0046 โ€” Sherman Oaks, California
  • Local Institution - 0106 โ€” Danbury, Connecticut
  • Local Institution - 0148 โ€” New Haven, Connecticut
  • Local Institution - 0056 โ€” New Haven, Connecticut
  • Local Institution - 0153 โ€” Stamford, Connecticut
  • Local Institution - 0022 โ€” Altamonte Springs, Florida
  • Local Institution - 0048 โ€” Atlantis, Florida
  • Local Institution - 0228 โ€” Boca Raton, Florida
  • Local Institution - 0250 โ€” Boca Raton, Florida

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—