A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss, Fat Loss, and Lean Mass Preservation (NCT06299098)
A Randomized, Double-Blind Study of The Efficacy and Safety of Trevogrumab, With or Without Garetosmab, in Addition to Semaglutide in Patients With Obesity
🩺 Plain-English Summary (8th-Grade Level)
This study is researching experimental drugs called trevogrumab and garetosmab (called "study drugs") in combination with another drug, semaglutide (Wegovy®). This study will be done in 3 parts, Part A, Part B, and Part C where different study drugs will be tested. Part A of the study is focused on healthy participants. Part B and C of the study is focused on participants with obesity. The aim of Part A of the study is to see how safe and tolerable the study drug is in healthy participants. The aim of Part B and Part C of the study is to see how safe and effective the study drug is when combined with Wegovy. Parts A, B, and C of the study are looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)
Who can join: Review the eligibility criteria below.
Location: Pinnacle Research Group — Anniston, Alabama
Age range: 18 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (60 Sites)
Showing the first 25 of 60 sites.
- Pinnacle Research Group — Anniston, Alabama
- Cullman Clinical Trials — Cullman, Alabama
- Foothills Research Center Cct Research — Phoenix, Arizona
- Anaheim Clinical Trials — Anaheim, California
- ProSciento — Chula Vista, California
- Valiance Clinical Research- Huntington Park — Huntington Park, California
- Velocity, San Diego — La Mesa, California
- Northern California Research — Sacramento, California
- Acclaim Clinical Research — San Diego, California
- Metabolic Institute of America — Tarzana, California
- Valiance Clinical Research — Tarzana, California
- Southwest General Healthcare Center — Fort Myers, Florida
- Westside Center for Clinical Research — Jacksonville, Florida
- Jacksonville Center for Clinical Research — Jacksonville, Florida
- IMA Clinical Research St. Petersburg — St. Petersburg, Florida
- Precision Clinical Research, LLC — Sunrise, Florida
- Clinical Research of West Florida, Inc. — Tampa, Florida
- Clinical Research of Central Florida - Bond Clinic — Winter Haven, Florida
- Center for Advanced Research and Education — Gainesville, Georgia
- Balanced Life Health Care Solutions — Lawrenceville, Georgia
- North Georgia Clinical Research — Woodstock, Georgia
- East-West Medical Research Institute — Honolulu, Hawaii
- Elite Clinical Trials LLLP — Blackfoot, Idaho
- Prairie Education and Research Cooperative (PERC) — Springfield, Illinois
- The South Bend Clinic Center for Research — South Bend, Indiana
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- SCALE KIDS: Research Study to Look at How Well a New Medicine is at Lowering Weight in Children With Obesity — Tucson, Arizona
- Piloting a Patient Navigator Program for Weight Loss — Philadelphia, Pennsylvania
- Study to Explore the Safety and Efficacy of NT-0796 as an Adjunct to Semaglutide in Participants With Obesity (RESOLVE-2) — Mesa, Arizona
- Effect of Prolonged (72 Hour) Glucagon Administration on Energy Expenditure in Healthy Obese Subjects — Orlando, Florida
- Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans — Pittsburgh, Pennsylvania
Explore by condition: All Obesity clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.