A Study to Assess IPN01194 When Administered Alone in Adults With Advanced Solid Tumours (NCT06305247)
An Open-label, Phase I/IIa First-in-human, Dose Escalation and Cohort Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic and Antitumour Activity of ERK1/2 Inhibitor IPN01194 as Single Agent in Adult Participants With Advanced Solid Tumours
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to determine the appropriate dosage, safety and effectiveness of the study drug, IPN01194 in adults with advanced solid tumours. The participants in this study will have advanced solid tumours. 'Advanced solid tumours' refers to cancers that can occur in several places, including cancers in organs or tissues that have spread from their original site to nearby tissues or other parts of the body. In this study, all participants will receive the study drug, which will be taken by mouth (orally).
Who can join: Review the eligibility criteria below.
Location: The Angeles Clinic and Research Institute - California — Los Angeles, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (11 Sites)
- The Angeles Clinic and Research Institute - California — Los Angeles, California
- Yale Cancer Center - New Heaven — New Haven, Connecticut
- Sarah Cannon Research Institute (SCRI) - Nashville — Nashville, Tennessee
- Virginia Cancer Specialist — Fairfax, Virginia
- Centre Léon Bérard - Lyon — Lyon,
- Paris Saint-Louis — Paris,
- Institut de Cancerologie de l'Ouest (St-Herblain) — Saint-Herblain,
- IGR-Villejuif — Villejuif,
- Barcelona - Val D'Hebron — Barcelona,
- Fundacion Jimenez Diaz - Madrid — Madrid,
- M.D. Anderson Cancer Center Madrid — Madrid,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.