๐๏ธ Verified NIH Record โข Updated 2026-07-17
Study to Evaluate Avacopan in Combination With a Rituximab or Cyclophosphamide-containing Regimen, in Children From 6 Years to < 18 Years of Age With AAV. (NCT06321601)
A Phase 3, Open-label, Uncontrolled Single-arm Study to Evaluate the Efficacy, Pharmacokinetics, and Safety of Avacopan in Combination With a Rituximab or a Cyclophosphamide-containing Regimen in Children From 6 Years to < 18 Years of Age With Active ANCA-associated Vasculitis (AAV)
๐ต Active, Not Recruiting Phase3 ๐ Investigational Drug / Biologic Sponsor: Amgen
๐ฉบ Plain-English Summary (8th-Grade Level)
The main objective of this study is to explore the efficacy of avacopan in participants affected by AAV.
Who can join: Review the eligibility criteria below.
Location: Emory University โ Atlanta, Georgia
Age range: 6 Years to 17 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (34 Sites)
Showing the first 25 of 34 sites.
- Emory University โ Atlanta, Georgia
- Riley Hospital for Children โ Indianapolis, Indiana
- University of Minnesota Masonic Childrens Hospital Discovery Clinic โ Minneapolis, Minnesota
- Cohen Children Medical Center โ Lake Success, New York
- University of North Carolina โ Chapel Hill, North Carolina
- Wake Forest University Health Sciences โ Charlotte, North Carolina
- Akron Childrens Hospital โ Akron, Ohio
- Cleveland Clinic Foundation โ Cleveland, Ohio
- University of Pittsburgh Medical Center Childrens Hospital of Pittsburgh โ Pittsburgh, Pennsylvania
- Texas Childrens Hospital โ Houston, Texas
- Universitair Ziekenhuis Gent โ Ghent,
- Universitair Ziekenhuis Leuven - Gasthuisberg โ Leuven,
- Alberta Childrens Hospital โ Calgary, Alberta
- Stollery Childrens Hospital โ Edmonton, Alberta
- British Columbia Childrens Hospital โ Vancouver, British Columbia
- CHU Sainte Justine โ Montreal, Quebec
- Vseobecna fakultni nemocnice v Praze โ Prague,
- Fakultni nemocnice Motol a Homolka โ Prague,
- Centre Hospitalier Universitaire de Bordeaux - Hopital Pellegrin โ Bordeaux,
- Hospices Civils de Lyon Hopital Femme Mere Enfant โ Bron,
- Hopital Necker Enfants Malades โ Paris,
- Hopital Necker โ Paris,
- Semmelweis Egyetem โ Budapest,
- Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar โ Szeged,
- Uniwersyteckie Centrum Kliniczne โ Gdansk,
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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Explore by condition: All Vasculitis clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.