O. Formigenes Colonization in Calcium Oxalate Kidney Stone Disease (NCT06330246)
Oxalobacter Formigenes Colonization in Calcium Oxalate Kidney Stone Formers
🩺 Plain-English Summary (8th-Grade Level)
The goal of this trial is to test if colonization with the gut bacteria Oxalobacter formigenes leads to a reduction in urinary oxalate excretion in patients with calcium oxalate kidney stone disease. The study will recruit adult participants with a history of calcium oxalate kidney stones who are not colonized with Oxalobacter formigenes. Participants will * ingest fixed diets containing low and moderately high amounts of oxalate for 4 days at a time * collect urine, blood and stool samples during the fixed diets * ingest a preparation of live Oxalobacter formigenes to induce colonization with Oxalobacter formigenes
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham — Birmingham, Alabama
Age range: 18 Years to 70 Years
🧪 Interventions in This Study
- Low oxalate fixed diets pre-colonization (DIETARY_SUPPLEMENT)
- Moderately high oxalate fixed diets pre-colonization (DIETARY_SUPPLEMENT)
- Colonization with Oxalobacter formigenes (DIETARY_SUPPLEMENT)
- Low oxalate fixed diets post-colonization (DIETARY_SUPPLEMENT)
- Moderately high oxalate fixed diets post-colonization (DIETARY_SUPPLEMENT)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (2 Sites)
- University of Alabama at Birmingham — Birmingham, Alabama
- UTSW — Dallas, Texas
📞 Contact the Study Coordinator
Phone: (205) 975-6932
Email: sfargue@uab.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.