🏛️ Verified NIH Record • Updated 2026-07-30
A Study of EDG-7500 in Adults With Hypertrophic Cardiomyopathy (CIRRUS-HCM) (NCT06347159)
An Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of EDG-7500 in Adults With Hypertrophic Cardiomyopathy
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Edgewise Therapeutics, Inc.
🩺 Plain-English Summary (8th-Grade Level)
This study is being conducted in order to understand the safety and effects of different doses of EDG-7500 as a single dose in adults with obstructive hypertrophic cardiomyopathy (oHCM) and as multiple doses in adults with obstructive or nonobstructive hypertrophic cardiomyopathy (nHCM).
Who can join: Review the eligibility criteria below.
Location: University of California, San Francisco — San Francisco, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (21 Sites)
- University of California, San Francisco — San Francisco, California
- Stanford University Hospital / Stanford Health Care — Stanford, California
- Emory Clinic — Atlanta, Georgia
- Massachusetts General Hospital — Boston, Massachusetts
- Brigham and Womens Hospital — Boston, Massachusetts
- Lahey Hospital and Medical Center — Burlington, Massachusetts
- Michigan Medicine - Michigan Clinical Research Unit — Ann Arbor, Michigan
- Saint Luke's Hospital of Kansas City — Kansas City, Missouri
- Morristown Medical Center (Atlantic Health System) — Morristown, New Jersey
- North Shore University Hospital — Manhasset, New York
- NYU Langone Health Medical Center - HCM Program Office (Study open to existing NYU patients only) — New York, New York
- Sanger Heart and Vascular Institute — Charlotte, North Carolina
- Duke Health Center Arringdon — Morrisville, North Carolina
- The Lindner Research Center at Christ Hospital — Cincinnati, Ohio
- University Hospitals Cleveland Medical Center — Cleveland, Ohio
- Cleveland Clinic — Cleveland, Ohio
- Oregon Health & Science University (OHSU) — Portland, Oregon
- Hospital of the University of Pennsylvania (University of Pennsylvania School of Medicine) — Philadelphia, Pennsylvania
- Medical University of South Carolina — Charleston, South Carolina
- University of Virginia Heart and Vascular Center Fontaine — Charlottesville, Virginia
- Virginia Mason Medical Center — Seattle, Washington
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Hypertrophic Cardiomyopathy
- A Prospective Incident Study of Arrhythmias in Hypertrophic Cardiomyopathy — Rochester, Minnesota
- HCMR - Novel Markers of Prognosis in Hypertrophic Cardiomyopathy — New Haven, Connecticut
- A Study of Artificial Intelligence ECG With ECG Devices to Detect Hypertrophic Cardiomyopathy Distinct From Athlete's — Rochester, Minnesota
- Exercise Intolerance in Non-obstructive Hypertrophic Cardiomyopathy — San Francisco, California
- VIZ ACCESS HCM - Multi-Site Registry — Atlanta, Georgia
Explore by condition: All Hypertrophic Cardiomyopathy clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.