Study of JK07 in Patients With Chronic Heart Failure (NCT06369298)
A Phase 2 Randomized, Double-blind, Placebo-controlled Study to Assess the Safety and Efficacy of JK07 in Adults With Chronic Heart Failure (RENEU-HF)
🩺 Plain-English Summary (8th-Grade Level)
This is a Phase 2, randomized, double-blind, placebo-controlled, multiple dose study to assess the safety, tolerability, and efficacy of JK07 in participants aged 18-85 with heart failure. There will be 2 cohorts in this study: Cohort 1: Heart failure (HF) participants with left ventricular ejection fraction (LVEF) of ≤ 40%. Cohort 2: Heart failure (HF) participants with left ventricular ejection fraction (LVEF) \> 40% and ≤ 65%.
Who can join: Review the eligibility criteria below.
Location: Site 121 — Alexander City, Alabama
Age range: 18 Years to 85 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (62 Sites)
Showing the first 25 of 62 sites.
- Site 121 — Alexander City, Alabama
- Site 130 — Birmingham, Alabama
- Site 139 — Birmingham, Alabama
- Site 138 — Huntsville, Alabama
- Site 111 — Phoenix, Arizona
- Site 127 — Little Rock, Arkansas
- Site 128 — Huntington Beach, California
- Site 157 — Los Angeles, California
- Site 158 — Orange, California
- Site 116 — Pasadena, California
- Site 129 — Santa Maria, California
- Site 102 — Stanford, California
- Site 113 — Torrance, California
- Site 133 — Vista, California
- Site 161 — Coral Gables, Florida
- Site 114 — Hialeah, Florida
- Site 162 — Miami Lakes, Florida
- Site 159 — Naples, Florida
- Site 136 — Atlanta, Georgia
- Site 143 — Boise, Idaho
- Site 160 — Chicago, Illinois
- Site 154 — Park Ridge, Illinois
- Site 137 — Fort Wayne, Indiana
- Site 112 — Indianapolis, Indiana
- Site 104 — Covington, Louisiana
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Heart Failure With Reduced Ejection Fraction
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- Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure — Baltimore, Maryland
- PRIME HFrEF: Novel Exercise for Older Patients With Heart Failure With Reduced Ejection Fraction — Charlottesville, Virginia
- Conduction System Vs Surgical Left Ventricular Epicardial Pacing For Coronary Sinus Lead Failure — Overland Park, Kansas
- Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure — Tulsa, Oklahoma
Explore by condition: All Heart Failure With Reduced Ejection Fraction clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.