Theta-Burst Stimulation for Bipolar Depression (NCT06370988)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this trial is to determine if intermittent theta-burst stimulation (iTBS) can reduce the symptoms of depression in treatment-resistant bipolar disorder. To do this, some of the participants in this study will receive treatment with active iTBS stimulation, while others will receive sham iTBS stimulation. Participants will come for 30 days of either active iTBS or sham iTBS, with a 6-week follow-up period. Symptoms of depression (for determining treatment efficacy) and mania (for determining treatment safety) will be assessed using the 17-item Hamilton Rating Scale for Depression (HRSD-17) and the Young Mania Rating Scale (YMRS) every five treatments during the treatment course, and at 1 week and 6 week after treatment completion.
Who can join: Review the eligibility criteria below.
Location: University Health Network — Toronto, Ontario
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (2 Sites)
- University Health Network — Toronto, Ontario
- Centre for Addiction and Mental Health — Toronto, Ontario
📞 Contact the Study Coordinator
Phone: (416) 535-8501
Email: Elizabeth.Clancy@camh.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Bipolar Depression
- Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar Depression — Toronto, Ontario
- Probiotics to Prevent Relapse After Hospitalization for Bipolar Depression — Towson, Maryland
- Brexpiprazole Treatment for Bipolar I Depression — Hamilton, Ontario
- SYNCED - SYNChronized Eating in Bipolar Depression Study — Ottawa, Ontario
- Deep Brain Stimulation of Treatment-Resistant Bipolar Depression — Boston, Massachusetts
- Ketogenic Intervention for Bipolar Depression — Rochester, Minnesota
Explore by condition: All Bipolar Depression clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.