Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder (NCT06373016)
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is to test how specific components of diet affect brain function and behavior for individuals with bipolar. The main question it aims to answer is how glucose and ketones each affect the brain's response to risk and reward. Participants will be asked to provide blood (to assess baseline measures of how the body uses energy), and then to receive two MRI scan sessions, on separate days. During each MRI scan session, participants will play three games, from which they can win money, before and after drinking glucose (on one day) or ketones (on the other day). Investigators will compare individuals with and without bipolar to test whether the two groups differ in how their brains use energy, and to test how the brain's use of energy affects behavior.
Who can join: Review the eligibility criteria below.
Location: McLean Hospital — Belmont, Massachusetts
Age range: 18 Years to 45 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (3 Sites)
- McLean Hospital — Belmont, Massachusetts
- Martinos Center for Biomedical Research, Building 149, 13th Street — Charlestown, Massachusetts
- Laufer Center for Physical and Quantitative Biology , Stony Brook University — Stony Brook, New York
📞 Contact the Study Coordinator
Phone: (914) 325-0868
Email: stephen.j.burke@stonybrook.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Bipolar Disorder
- Early Intervention for Youth at High Risk for Bipolar Disorder — Pittsburgh, Pennsylvania
- Evaluation of the Genetics of Bipolar Disorder — Bethesda, Maryland
- Narrative Enhancement and Cognitive Therapy for Self-Stigma in Youth — Toronto, Ontario
- Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression — Belmont, Massachusetts
- Characterizing MyMood Patterns of Use — Toronto, Ontario
- A Future Thinking Intervention for Comorbid Tobacco Use Disorder and Bipolar Disorder — Boston, Massachusetts
Explore by condition: All Bipolar Disorder clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.