๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-27

A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer (NCT06385080)

A Phase 1b/2, Open-label Study of Amivantamab Monotherapy and Amivantamab in Addition to Other Therapeutic Agents in Participants With Head and Neck Squamous Cell Carcinoma

๐ŸŸข Recruiting Phase1 / Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Janssen Research & Development, LLC

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The purpose of this study is to determine safety and preliminary efficacy of amivantamab monotherapy, amivantamab in addition to pembrolizumab, amivantamab in addition to paclitaxel and amivantamab in addition to pembrolizumab and carboplatin in participants with recurrent/metastatic head and neck cancer. The study will also confirm the recommended Phase 2 combination dose (RP2CD) for amivantamab in addition to paclitaxel. The safety and preliminary efficacy of amivantamab in addition to pembrolizumab will also be determined in perioperative (before and after surgery) setting in participants with resectable locally advanced head and neck squamous cell carcinoma (HNSCC).

Who can join: Review the eligibility criteria below.

Location: University of California at San Diego Moores Cancer Center โ€” La Jolla, California

Age range: 18 Years

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (56 Sites)

Showing the first 25 of 56 sites.

  • University of California at San Diego Moores Cancer Center โ€” La Jolla, California
  • University of Colorado Denver Anschultz Medical Campus โ€” Aurora, Colorado
  • Yale Cancer Center โ€” New Haven, Connecticut
  • The University of Chicago Medical Center (UCMC) โ€” Chicago, Illinois
  • University of Maryland School of Medicine โ€” Baltimore, Maryland
  • Dana Farber Cancer Institute โ€” Boston, Massachusetts
  • University of Michigan Rogel Cancer Center โ€” Ann Arbor, Michigan
  • Karmanos Cancer Institute โ€” Detroit, Michigan
  • Washington University School Of Medicine โ€” St Louis, Missouri
  • Rutgers Cancer Institute of New Jersey โ€” New Brunswick, New Jersey
  • University of North Carolina at Chapel Hill โ€” Chapel Hill, North Carolina
  • Cleveland Clinic โ€” Cleveland, Ohio
  • University of Utah Huntsman Cancer Institute โ€” Salt Lake City, Utah
  • University of Virginia โ€” Charlottesville, Virginia
  • Virginia Cancer Specialists โ€” Fairfax, Virginia
  • Beijing Cancer Hospital of Peking University โ€” Beijing,
  • West China School of Medicine/West China Hospital, Sichuan University โ€” Cheng Du Shi,
  • Linyi Cancer Hospital โ€” Linyi,
  • Fudan Cancer Hospital โ€” Shanghai,
  • Shanghai East Hospital โ€” Shanghai,
  • Union Hospital Tongji Medical College of Huazhong University of Science and Technology โ€” Wuhan,
  • Institut Sainte Catherine โ€” Avignon,
  • Centre Oscar Lambret โ€” Lille,
  • CHU Nantes โ€” Nantes,
  • Institut Curie โ€” Paris,

๐Ÿ“ž Contact the Study Coordinator

Phone: (844) 434-4210

Email: Participate-In-This-Study1@its.jnj.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—