The Role of Vitamin K on Knee Osteoarthritis Outcomes (NCT06385275)
🩺 Plain-English Summary (8th-Grade Level)
The appropriate form and dosing of vitamin K to benefit relevant outcomes in knee osteoarthritis (OA) are not known. In intervention studies for conditions other than knee OA (e.g., prevention of cardiovascular disease), the most commonly used forms and doses include phylloquinone (vitamin K1; 1000µg or 500µg daily) or menaquinone-7 (MK-7 or vitamin K2; 300µg daily). However, whether these doses are adequate to increase vitamin K to levels that ameliorate risk of adverse OA outcomes is not known. Furthermore, although some studies suggest enhanced bioavailability of MK-7 over vitamin K1, as well as extra-hepatic effects, whether this is relevant for an older population with knee OA is not known, The overall goal of this pilot randomized clinical trial (RCT) is to test different subtypes and doses of vitamin K supplementation in older adults with knee OA and to measure changes in relevant biochemical measures.
Who can join: Review the eligibility criteria below.
Location: Boston Medical Center, Rheumatology Clinic — Boston, Massachusetts
Age range: 50 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Boston Medical Center, Rheumatology Clinic — Boston, Massachusetts
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Osteo Arthritis Knee
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- Radiographic Migration Analysis of the ATTUNE Cementless CR Fixed-Bearing Total Knee Replacement — Winnipeg, Manitoba
- Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis: — Boston, Massachusetts
- Geniculate Artery Embolization for Osteoarthritis — Minneapolis, Minnesota
- Analgesic Potential of Light Therapy in Knee Osteoarthritis — Halifax, Nova Scotia
Explore by condition: All Osteo Arthritis Knee clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.