EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD) (NCT06401421)
EXActDNA-003 / NSABP B-64: Breast Cancer Clinical Validation Study to Predict Recurrence of High-Risk Early Breast Cancer Treated With Neoadjuvant Therapy Using a Bespoke Circulating Tumor DNA Assay to Detect Molecular Residual Disease
🩺 Plain-English Summary (8th-Grade Level)
The EXActDNA-003 study will prospectively enroll participants who are planning to undergo chemotherapy for high-risk, early breast cancer, who are willing to provide tissue and blood specimens for circulating tumor DNA (ctDNA) analysis. Participants will be followed for up to 5.5 years.
Who can join: Review the eligibility criteria below.
Location: Katmai Oncology Group - Anchorage — Anchorage, Alaska
Age range: 18 Years
🧪 Interventions in This Study
- ctDNA MRD test (DIAGNOSTIC_TEST)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (58 Sites)
Showing the first 25 of 58 sites.
- Katmai Oncology Group - Anchorage — Anchorage, Alaska
- Stanford Cancer Institute — Palo Alto, California
- Harbor-UCLA Medical Center - Hematology / Oncology — Torrance, California
- Kaiser Permanente Medical Center — Vallejo, California
- UCHealth Cancer Care - Anschutz Medical Campus - University of Colorado Cancer Center — Aurora, Colorado
- AdventHealth East Altamonte Oncology and Hematology — Altamonte Springs, Florida
- Mount Sinai Medical - Comprehensive Cancer Center — Miami Beach, Florida
- Baptist Cancer Care - Plantation — Plantation, Florida
- St. Joseph's Women's Hospital — Tampa, Florida
- Rush Cancer Center — Chicago, Illinois
- Deaconess Chancellor Center for Oncology — Newburgh, Indiana
- University of Kansas Cancer Center — Westwood, Kansas
- St. Elizabeth Edgewood Hospital — Edgewood, Kentucky
- Norton Cancer Institute - Downtown — Louisville, Kentucky
- Baptist Health Louisville — Louisville, Kentucky
- Weinberg Center at Mercy — Baltimore, Maryland
- Greater Baltimore Medical Center — Baltimore, Maryland
- Sinai Hospital of Baltimore — Baltimore, Maryland
- MedStar Georgetown Cancer Institute — Baltimore, Maryland
- The Center for Cancer and Blood Disorders - Bethesda — Bethesda, Maryland
- James M Stockman Cancer Institute — Frederick, Maryland
- Tate Cancer Center at UM Baltimore Washington — Glen Burnie, Maryland
- Meritus Center for Clinical Research — Hagerstown, Maryland
- Holy Cross Hospital - Silver Spring — Silver Spring, Maryland
- University of Maryland St. Joseph Medical Center — Towson, Maryland
📞 Contact the Study Coordinator
Phone: (800) 270-3165
Email: industry.trials@nsabp.org
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.