A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy (NCT06413706)

🧪 Interventions in This Study

• Abemaciclib (DRUG)
• Temozolomide (DRUG)

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (37 Sites)

Showing the first 25 of 37 sites.

• Children's Hospital of Orange County - Orange — Orange, California
• Lucile Packard Children's Hospital (LPCH) - Stanford University — Palo Alto, California
• Riley Hospital for Children at Indiana University Health — Indianapolis, Indiana
• The Johns Hopkins Hospital (JHH) - Johns Hopkins Childrens Center — Baltimore, Maryland
• University of Michigan Health System (UMHS) - C.S. Mott Children's Hospital - Hematology Oncology Clinic — Ann Arbor, Michigan
• Mayo Clinic — Rochester, Minnesota
• Rhode Island Hospital — Providence, Rhode Island
• UT Southwestern Medical Center Dallas/Childrens Medical Center — Dallas, Texas
• The University of Texas MD Anderson Cancer Center — Houston, Texas
• Queensland Government- Lady Cilento Children's Hospital — Brisbane,
• Perth Children's Hospital — Nedlands,
• The Children's Hospital at Westmead — Westmead,
• Universitair Ziekenhuis Gent (Uz Gent) — Ghent,
• Universitair Ziekenhuis Leuven — Leuven,
• Universite Catholique de Louvain (UCL) - Cliniques Universitaires Saint-Luc — Woluwe-Saint-Lambert,
• Copenhagen University Hospital-Rigshospitalet University Hospital — Copenhagen,
• Centre Hospitalier Universitaire de Bordeaux Groupe Hospitalier Pellegrin Hopital des Enfants — Bordeaux,
• Centre de Lutte Contre le Cancer (CLCC) - Centre Oscar Lambret — Lille,
• Centre Leon Berard — Lyon,
• Hopital La Timone — Marseille,
• Institut Curie — Paris,
• Institut Gustave Roussy-Gustave Roussy Cancer Center -DITEP — Villejuif,
• Fondazione IRCCS Istituto Nazionale dei Tumori — Milan,
• Azienda Ospedaliera Di Rilievo Nazionale Santobono Pausilipon — Naples,
• IRCCS Ospedale Pediatrico Bambino Gesu — Rome,

💰 Cost, Insurance & Patient Rights

• 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
• Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
• Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in Glioma

• Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis — Bethesda, Maryland
• Pembrolizumab (MK-3475) in Patients With Recurrent Malignant Glioma With a Hypermutator Phenotype — Los Angeles, California
• Cognitive Changes of IDH-mutant and IDH-wildtype Glioma Patients After Chemoradiotherapy With Radiation Dose to the Resting State Networks — St Louis, Missouri
• Simultaneous Multinuclear Metabolic MRI in Newly Diagnosed or Recurrent Glioma — Los Angeles, California
• Simulation-Based Caregiving Skills Training for Family Members of High Grade Glioma Patients — Houston, Texas
• ExAblate (Magnetic Resonance-guided Focused Ultrasound Surgery) Treatment of Brain Tumors — Toronto, Ontario

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💡 How to Participate

1. Check the checklist above to see if you may qualify.
2. Review the official NIH record below to find the coordinating site.
3. Ask about the visit schedule, what is covered at no cost, and any travel support.
4. Confirm with your own doctor before making a decision.