Thermogenic Silencer Regulatory Factors in Humans (NCT06424132)
Identification of Thermogenic Silencing Regulatory Factors as Biomarkers of Metabolic Health in Humans
🩺 Plain-English Summary (8th-Grade Level)
A promising approach to correct the metabolic dysfunction associated with obesity is to activate brown fat non-shivering thermogenesis (NST). A critical limitation with NST as a therapeutic option, however, is that this beneficial process is silenced under human physiological temperature conditions and the mechanisms of how this occurs is unknown. This study will be the first to identify human NST silencing factors that may be targeted for the treatment of obesity and metabolic disorders.
Who can join: Review the eligibility criteria below.
Location: Rockefeller University — New York, New York
Age range: 18 Years to 35 Years
🧪 Interventions in This Study
- Cold Vest Exposure Period (OTHER)
- Rewarming Exposure Period (OTHER)
- Fasting (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Rockefeller University — New York, New York
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.