🏛️ Verified NIH Record • Updated 2026-07-28

A Phase 1 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors (NCT06427941)

A Phase 1 Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Selected Advanced or Metastatic Solid Tumors

🟢 Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: BeOne Medicines

🩺 Plain-English Summary (8th-Grade Level)

This is a first-in-human (FIH) clinical study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and anti-tumor activity of BGB-B2033 administered as monotherapy and in combination with tislelizumab, with or without bevacizumab. The study will enroll participants with locally advanced or metastatic hepatocellular carcinoma (HCC), alpha-fetoprotein (AFP)-producing gastric cancer (GC), extragonadal yolk sac tumors/non-dysgerminomas, or glypican-3 (GPC3)-positive squamous non-small cell lung cancer (NSCLC).

Who can join: Review the eligibility criteria below.

Location: City of Hope Phoenix Cancer Center — Goodyear, Arizona

Age range: 18 Years

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (48 Sites)

Showing the first 25 of 48 sites.

  • City of Hope Phoenix Cancer Center — Goodyear, Arizona
  • City of Hope National Medical Center — Duarte, California
  • City of Hope Chicago Cancer Center — Zion, Illinois
  • Memorial Sloan Kettering Cancer Center Mskcc — New York, New York
  • Upmc Hillman Cancer Center(Univ of Pittsburgh) — Pittsburgh, Pennsylvania
  • Scri Oncology Partners — Nashville, Tennessee
  • The University of Texas Md Anderson Cancer Center — Houston, Texas
  • Centro Gaucho Integrado de Oncologia Hospital Mae de Deus — Porto Alegre,
  • Hospital Da Bahia — Salvador,
  • Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto — São José do Rio Preto,
  • Icesp Instituto Do Cancer Do Estado de Sao Paulo Octavio Frias de Oliveira — São Paulo,
  • Anhui Provincial Hospital — Hefei, Anhui
  • Chongqing University Cancer Hospital — Chongqing, Chongqing Municipality
  • Mengchao Hepatobiliary Hospital of Fujian Medical University — Fuzhou, Fujian
  • Zhujiang Hospital of Southern Medical University — Guangzhou, Guangdong
  • Nanfang Hospital of Southern Medical University — Guangzhou, Guangdong
  • Guangxi Medical University Cancer Hospital Wuxiang Branch — Nanning, Guangxi
  • The Fourth Hospital of Hebei Medical University — Shijiazhuang, Hebei
  • Harbin Medical University Cancer Hospital — Harbin, Heilongjiang
  • Union Hospital of Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei
  • Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology — Wuhan, Hubei
  • Hunan Cancer Hospital — Changsha, Hunan
  • The Affiliated Hospital of Xuzhou Medical University — Xuzhou, Jiangsu
  • The Second Affiliated Hospital of Nanchang University — Nanchang, Jiangxi
  • The Second Affiliated Hospital of Nanchang Universityhongjiaozhou Branch — Nanchang, Jiangxi

📞 Contact the Study Coordinator

Phone: (877) 828-5568

Email: clinicaltrials@beonemed.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗