A Phase 1 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors (NCT06427941)
A Phase 1 Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Selected Advanced or Metastatic Solid Tumors
🩺 Plain-English Summary (8th-Grade Level)
This is a first-in-human (FIH) clinical study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and anti-tumor activity of BGB-B2033 administered as monotherapy and in combination with tislelizumab, with or without bevacizumab. The study will enroll participants with locally advanced or metastatic hepatocellular carcinoma (HCC), alpha-fetoprotein (AFP)-producing gastric cancer (GC), extragonadal yolk sac tumors/non-dysgerminomas, or glypican-3 (GPC3)-positive squamous non-small cell lung cancer (NSCLC).
Who can join: Review the eligibility criteria below.
Location: City of Hope Phoenix Cancer Center — Goodyear, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (48 Sites)
Showing the first 25 of 48 sites.
- City of Hope Phoenix Cancer Center — Goodyear, Arizona
- City of Hope National Medical Center — Duarte, California
- City of Hope Chicago Cancer Center — Zion, Illinois
- Memorial Sloan Kettering Cancer Center Mskcc — New York, New York
- Upmc Hillman Cancer Center(Univ of Pittsburgh) — Pittsburgh, Pennsylvania
- Scri Oncology Partners — Nashville, Tennessee
- The University of Texas Md Anderson Cancer Center — Houston, Texas
- Centro Gaucho Integrado de Oncologia Hospital Mae de Deus — Porto Alegre,
- Hospital Da Bahia — Salvador,
- Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto — São José do Rio Preto,
- Icesp Instituto Do Cancer Do Estado de Sao Paulo Octavio Frias de Oliveira — São Paulo,
- Anhui Provincial Hospital — Hefei, Anhui
- Chongqing University Cancer Hospital — Chongqing, Chongqing Municipality
- Mengchao Hepatobiliary Hospital of Fujian Medical University — Fuzhou, Fujian
- Zhujiang Hospital of Southern Medical University — Guangzhou, Guangdong
- Nanfang Hospital of Southern Medical University — Guangzhou, Guangdong
- Guangxi Medical University Cancer Hospital Wuxiang Branch — Nanning, Guangxi
- The Fourth Hospital of Hebei Medical University — Shijiazhuang, Hebei
- Harbin Medical University Cancer Hospital — Harbin, Heilongjiang
- Union Hospital of Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei
- Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology — Wuhan, Hubei
- Hunan Cancer Hospital — Changsha, Hunan
- The Affiliated Hospital of Xuzhou Medical University — Xuzhou, Jiangsu
- The Second Affiliated Hospital of Nanchang University — Nanchang, Jiangxi
- The Second Affiliated Hospital of Nanchang Universityhongjiaozhou Branch — Nanchang, Jiangxi
📞 Contact the Study Coordinator
Phone: (877) 828-5568
Email: clinicaltrials@beonemed.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.