A Study to Assess the Efficacy and Safety of Satralizumab in Duchenne Muscular Dystrophy (DMD) (NCT06450639)
A Phase II Multicenter, Open-label Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Pediatric Patients With Duchenne Muscular Dystrophy (SHIELD DMD)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to assess the efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of satralizumab, a humanized anti-interleukin-6 receptor (aIL-6R) monoclonal antibody, in ambulatory and non-ambulatory participants with DMD aged ≥ 8 to \< 18 years old receiving corticosteroid therapy.
Who can join: Review the eligibility criteria below.
Location: Arkansas Children's Hospital — Little Rock, Arkansas
Age range: 8 Years to 17 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (18 Sites)
- Arkansas Children's Hospital — Little Rock, Arkansas
- University of California Davis Medical Center — Sacramento, California
- Children's Healthcare of Atlanta Center for Advanced Pediatrics — Atlanta, Georgia
- Corewell Health — Grand Rapids, Michigan
- Neurology Rare Disease Center — Flower Mound, Texas
- Child's Hosp King's Daughters — Norfolk, Virginia
- Rigshospitalet;Klinik for Børn og Unge med Hjerne- og Nervesygdomme — København Ø,
- Policlinico Agostino Gemelli — Rome, Lazio
- Fondazione IRCCS Istituto Neurologico ?Carlo Besta? — Milan, Lombardy
- Uniwersyteckie Centrum Kliniczne — Gdansk,
- Instytut Centrum Zdrowia Matki Polki — Lodz,
- Uniwersyteckie Centrum Kliniczne WUM, Centralny Szpital Kliniczny — Warsaw,
- Hospital Sant Joan De Deu — Esplugues de Llobregas, Barcelona
- Hospital U. Central de Asturias — Asturias, Principality of Asturias
- Hospital Universitario Torrecardenas;Servicio de Neurologia — Almería,
- Hospital Universitario la Fe — Valencia,
- Ohmatdyt - National Specialized children's hospital of MoH of Ukraine — Kyiv,
- Lvivska oblasna tsentralna likarnia — Lviv,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Duchenne Muscular Dystrophy
- Study to Evaluate the Safety and Efficacy of PF-06939926 for the Treatment of Duchenne Muscular Dystrophy — Little Rock, Arkansas
- Characterization of Clinical Skeletal and Cardiac Impairment in Carriers of DMD and BMD — Columbus, Ohio
- Microdystrophin Gene Transfer Study in Adolescents and Children With DMD — Los Angeles, California
- NS-050/NCNP-03 in Boys With DMD (Meteor50) — Los Angeles, California
- Pediatric Radio Frequency Coils Generic — Cincinnati, Ohio
Explore by condition: All Duchenne Muscular Dystrophy clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.