Effect of C-peptide on Hypoglycemic Counterregulation (NCT06470295)
On the Regulation of Hepatic Glucose Metabolism During Insulin-induced Hypoglycemia
🩺 Plain-English Summary (8th-Grade Level)
Iatrogenic hypoglycemia is the most prominent barrier to the safe, effective management of blood sugar in people with type 1 diabetes due to periodic over-insulinization. During insulin-induced hypoglycemia, glucagon secretion is diminished in type 1 diabetes which, in turn, reduces hepatic glucose production and increases the depth and duration of hypoglycemic episodes. We have observed that the naturally occurring protein C-peptide increases glucagon secretion in dogs during insulin-induced hypoglycemia, which increases hepatic glucose production; the experiments in this application will shed light on the translation of this finding to the human.
Who can join: Review the eligibility criteria below.
Location: University of Cincinnati — Cincinnati, Ohio
Age range: 18 Years to 40 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- University of Cincinnati — Cincinnati, Ohio
📞 Contact the Study Coordinator
Phone: (513) 558-4437
Email: jason.winnick@uc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Hypoglycemia
- Mechanisms of Hypoglycemia in Patients Without Diabetes — Boston, Massachusetts
- Hypoglycemia and the Gut Microbiome — Boston, Massachusetts
- Glucagon Dose-Response in Patients With Post-Bariatric Hypoglycemia — Birmingham, Alabama
- Differing Levels of Hypoglycemia — Baltimore, Maryland
- Diagnosing and Treating Low Blood Sugar Levels — Bethesda, Maryland
Explore by condition: All Hypoglycemia clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.