A Phase 3b, Single-Arm Study of Aflibercept 8 mg Dosed Every 4 Weeks in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD) or Diabetic Macular Edema (DME) (NCT06491914)
A Phase 3b Single-Arm Study of Aflibercept 8 mg in Participants With Neovascular Age-Related Macular Degeneration (nAMD) or Diabetic Macular Edema (DME)
🩺 Plain-English Summary (8th-Grade Level)
This study is researching aflibercept high dose (HD), referred to as "study drug", with an experimental dosing regimen. The study is focused on participants with nAMD and DME that have been previously treated with anti-vascular endothelial growth factor (anti-VEGF) medications. The aim of the study is to see how safe and effective aflibercept HD injections are when given as frequently as every 4 weeks. The study is also looking at what side effects may happen from taking the study drug.
Who can join: Review the eligibility criteria below.
Location: Win Retina - Arcadia — Arcadia, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (54 Sites)
Showing the first 25 of 54 sites.
- Win Retina - Arcadia — Arcadia, California
- California Retina Consultants — Bakersfield, California
- Retina Specialists of Beverly Hills — Beverly Hills, California
- Salehi Retina Institute dba Retina Associates of Southern California — Huntington Beach, California
- South Coast Retina Center — Long Beach, California
- California Eye Specialists Medical Group, Inc. — Pasadena, California
- Retina Consultants of Southern California — Redlands, California
- Vrmg Inc — Sacramento, California
- Retina Consultants of Southern Colorado — Colorado Springs, Colorado
- Eye care Center of Northern Colorado doing business as Advanced Vision Research Institute — Longmont, Colorado
- Retina Group of New England — Waterford, Connecticut
- Advanced Research, LLC — Deerfield Beach, Florida
- Florida Retina Institute - Jacksonville — Jacksonville, Florida
- Florida Retina Consultants — Lakeland, Florida
- Florida Retina Institute - Orlando — Orlando, Florida
- Retina Speciality Institute - Pensacola, Florida — Pensacola, Florida
- Eye Associates of Pinellas — Pinellas Park, Florida
- Retina Vitreous Associates of Florida Saint Petersburg — St. Petersburg, Florida
- Retina Vitreous Associates of Florida — Tampa, Florida
- Center for Retina and Macular Disease — Winter Haven, Florida
- Georgia Retina — Marietta, Georgia
- Retina Consultants of Hawaii, Inc. — ‘Aiea, Hawaii
- University Retina and Macula Associates PC - Lemont — Lemont, Illinois
- Illinois Retina Associates — Oak Park, Illinois
- Cumberland Valley Retina Consultants-Ophthalmology — Hagerstown, Maryland
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Neovascular Age-Related Macular Degeneration
- A Safety and Efficacy Study of One-time SAR402663 in Adults With Neovascular Age-related Macular Degeneration — Phoenix, Arizona
- Effect of AIV007 by Periocular Administration in Subjects with Macular Edema Secondary to Neovascular Age-related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME) — Beverly Hills, California
- Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Axitinib Implant) in Subjects With Neovascular Age- Related Macular Degeneration — Gilbert, Arizona
- Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD — Glendale, California
- Safety and Efficacy of ADVM-022 in Treatment-Experienced Patients With Neovascular Age-related Macular Degeneration [LUNA] — Phoenix, Arizona
Explore by condition: All Neovascular Age-Related Macular Degeneration clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.