Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain (NCT06500455)
Phase III Trial of Single Fraction Stereotactic Radiosurgery (SRS) Versus Fractionated SRS (FSRS) for Intact Brain Metastases
🩺 Plain-English Summary (8th-Grade Level)
This phase III trial compares the effectiveness of fractionated stereotactic radiosurgery (FSRS) to usual care stereotactic radiosurgery (SRS) in treating patients with cancer that has spread from where it first started to the brain. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. FSRS delivers a high dose of radiation to the tumor over 3 treatments. SRS is a type of external radiation therapy that uses special equipment to position the patient and precisely give a single large dose of radiation to a tumor. FSRS may be more effective compared to SRS in treating patients with cancer that has spread to the brain.
Who can join: Review the eligibility criteria below.
Location: Banner University Medical Center - Tucson — Tucson, Arizona
Age range: 18 Years
🧪 Interventions in This Study
- Computed Tomography (PROCEDURE)
- Fractionated Stereotactic Radiation Therapy (RADIATION)
- Magnetic Resonance Imaging (PROCEDURE)
- Stereotactic Radiosurgery (RADIATION)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (270 Sites)
Showing the first 25 of 270 sites.
- Banner University Medical Center - Tucson — Tucson, Arizona
- University of Arizona Cancer Center-North Campus — Tucson, Arizona
- Mercy Hospital Fort Smith — Fort Smith, Arkansas
- University of Arkansas for Medical Sciences — Little Rock, Arkansas
- Kaiser Permanente-Anaheim — Anaheim, California
- Kaiser Permanente-Bellflower — Bellflower, California
- City of Hope Corona — Corona, California
- City of Hope Comprehensive Cancer Center — Duarte, California
- UC San Diego Health System - Encinitas — Encinitas, California
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care — Irvine, California
- City of Hope at Irvine Lennar — Irvine, California
- UC San Diego Moores Cancer Center — La Jolla, California
- City of Hope Antelope Valley — Lancaster, California
- Kaiser Permanente Los Angeles Medical Center — Los Angeles, California
- Cedars-Sinai Medical Center — Los Angeles, California
- Providence Queen of The Valley — Napa, California
- Kaiser Permanente-Ontario — Ontario, California
- UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange, California
- Stanford Cancer Institute Palo Alto — Palo Alto, California
- UC San Diego Medical Center - Hillcrest — San Diego, California
- Providence Medical Foundation - Santa Rosa — Santa Rosa, California
- City of Hope South Pasadena — South Pasadena, California
- City of Hope South Bay — Torrance, California
- City of Hope Upland — Upland, California
- John Muir Medical Center-Walnut Creek — Walnut Creek, California
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.