Ventilator Pressure and Optimization of Compliance and Hemodynamics (NCT06512935)
Ventilator Pressure and Optimization of Compliance and Hemodynamics: VPOCH Trial
🩺 Plain-English Summary (8th-Grade Level)
In preterm infants \< 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increase the cardiac output and improve oxygenation. This study may emphasize using point-of-care echocardiography along with electrical impedance tomography (EIT) to optimize ventilator settings in preterm infants. Infants will be randomized to a 4-hour crossover period of increasing and decreasing PEEP in random order from baseline to determine compliance, oxygenation, and cardiac hemodynamics at each step using echocardiography (ECHO) and EIT measurements. There will be a 15-minute washout period after changes prior to data collection.
Who can join: Review the eligibility criteria below.
Location: Univerisity of Alabama — Birmingham, Alabama
Age range: 7 Days to 30 Days
🧪 Interventions in This Study
- Increase in the PEEP followed by decrease in the PEEP (OTHER)
- Decrease in the PEEP followed by increase in the PEEP (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Univerisity of Alabama — Birmingham, Alabama
📞 Contact the Study Coordinator
Phone: (917) 214-9882
Email: ksbhatia@uabmc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.