Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer (NCT06513962)
Triptorelin and Protection of Ovarian Reserve in Adolescents and Young Adults With Cancer
🩺 Plain-English Summary (8th-Grade Level)
This phase III trial compares the effect of giving triptorelin vs no triptorelin in preventing ovarian damage in adolescents and young adults (AYAs) with cancer receiving chemotherapy with an alkylating agents. Alkylating agents are part of standard chemotherapy, but may cause damage to the ovaries. If the ovaries are not working well or completely shut down, then it will be difficult or impossible to get pregnant in the future. Triptorelin works by blocking certain hormones and causing the ovaries to slow down or pause normal activity. The triptorelin used in this study stays active in the body for 24 weeks or about 6 months after a dose is given. After triptorelin is cleared from the body, the ovaries resume normal activities. Adding triptorelin before the start of chemotherapy treatment may reduce the chances of damage to the ovaries.
Who can join: Review the eligibility criteria below.
Location: Children's Hospital of Alabama — Birmingham, Alabama
Age range: Not specified to 39 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (206 Sites)
Showing the first 25 of 206 sites.
- Children's Hospital of Alabama — Birmingham, Alabama
- University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
- USA Health Strada Patient Care Center — Mobile, Alabama
- Phoenix Childrens Hospital — Phoenix, Arizona
- Banner University Medical Center - Tucson — Tucson, Arizona
- Mercy Hospital Fort Smith — Fort Smith, Arkansas
- Arkansas Children's Hospital — Little Rock, Arkansas
- CARTI Cancer Center — Little Rock, Arkansas
- City of Hope Comprehensive Cancer Center — Duarte, California
- UC San Diego Moores Cancer Center — La Jolla, California
- Loma Linda University Medical Center — Loma Linda, California
- Mattel Children's Hospital UCLA — Los Angeles, California
- Kaiser Permanente-Oakland — Oakland, California
- Children's Hospital of Orange County — Orange, California
- Sutter Medical Center Sacramento — Sacramento, California
- UC San Diego Medical Center - Hillcrest — San Diego, California
- Rady Children's Hospital - San Diego — San Diego, California
- Children's Hospital Colorado — Aurora, Colorado
- Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center — Denver, Colorado
- Connecticut Children's Medical Center — Hartford, Connecticut
- Beebe Medical Center — Lewes, Delaware
- Beebe South Coastal Health Campus — Millville, Delaware
- Helen F Graham Cancer Center — Newark, Delaware
- Medical Oncology Hematology Consultants PA — Newark, Delaware
- Christiana Care Health System-Christiana Hospital — Newark, Delaware
📞 Contact the Study Coordinator
Phone: (205) 638-9285
Email: oncologyresearch@peds.uab.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Hematopoietic and Lymphatic System Neoplasm
- Evaluation of Broccoli Seed and Sprout Extract for Detoxification of Carcinogens in Firefighters — Tucson, Arizona
- Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors — Anchorage, Alaska
- Virtual Reality for Symptom Management in Patients Undergoing Hematopoietic Stem Cell Transplantation — Buffalo, New York
- Data-Driven Strategies for Patient Engagement About Cancer Clinical Trials — Los Angeles, California
- Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials — Fairbanks, Alaska
- On the BRINK: PhotoBiomodulation (PBM) for Mucositis in Patients Undergoing Allogeneic Hematopoietic Stem Cell TRansplant (HSCT) - Implementing the Evidence & Discovering New Knowledge — Duarte, California
Explore by condition: All Hematopoietic and Lymphatic System Neoplasm clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.