Anti-VEGF Gene Therapy Trial for Vestibular Schwannoma (NCT06517888)
A Phase 1/2 Trial of AAVAnc80-antiVEGF Gene Therapy in Individuals With Unilateral Vestibular Schwannoma
🩺 Plain-English Summary (8th-Grade Level)
This trial will evaluate the safety and tolerability of a single unilateral administration of one of three dose levels of AAVAnc80-antiVEGF and will evaluate the Akouos delivery device to safely achieve the intended product performance.
Who can join: Review the eligibility criteria below.
Location: Johns Hopkins Hospital — Baltimore, Maryland
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (4 Sites)
- Johns Hopkins Hospital — Baltimore, Maryland
- Mayo Clinic — Rochester, Minnesota
- Vanderbilt Bill Wilkerson Center — Nashville, Tennessee
- University of Texas Southwestern — Dallas, Texas
📞 Contact the Study Coordinator
Phone: (857) 410-1816
Email: AkouosClinicalTrials@Lilly.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Vestibular Schwannoma
- Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma — Boston, Massachusetts
- CI Following VS Removal or Labyrinthectomy — Columbus, Ohio
- Study of Aspirin in Patients With Vestibular Schwannoma — Stanford, California
- Evaluating Pre-Treatment Vestibular Physical Therapy Rehab for Patients With Vestibular Schwannomas — Milwaukee, Wisconsin
Explore by condition: All Vestibular Schwannoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.