A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1) (NCT06525220)
A Phase 3 Randomized, Open-label Study to Evaluate the Efficacy and Safety of Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Recurrent or Metastatic PD-L1+ Head and Neck Squamous Cell Carcinoma
🩺 Plain-English Summary (8th-Grade Level)
This is a Phase 3 randomized, open-label study to evaluate the efficacy and safety of petosemtamab plus pembrolizumab vs pembrolizumab in first-line treatment of recurrent or metastatic PD-L1+ head and neck squamous cell carcinoma.
Who can join: Review the eligibility criteria below.
Location: Site 164 — Mobile, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (205 Sites)
Showing the first 25 of 205 sites.
- Site 164 — Mobile, Alabama
- Site 36 — La Jolla, California
- Site 27 — Los Angeles, California
- Site 16 — Palo Alto, California
- Site 19 — Newark, Delaware
- Site 108 — Washington D.C., District of Columbia
- Site 14 — Fort Myers, Florida
- Site 48 — Orlando, Florida
- Site 8 — Orlando, Florida
- Site 21 — St. Petersburg, Florida
- Site 20 — West Palm Beach, Florida
- Site 171 — Atlanta, Georgia
- Site 197 — Chicago, Illinois
- Site 50 — Chicago, Illinois
- Site 2 — Louisville, Kentucky
- Site 162 — Baton Rouge, Louisiana
- Site 155 — Minneapolis, Minnesota
- Site 168 — St Louis, Missouri
- Site 94 — Hackensack, New Jersey
- Site 6 — Albuquerque, New Mexico
- Site 113 — Durham, North Carolina
- Site 118 — Winston-Salem, North Carolina
- Site 191 — Cleveland, Ohio
- Site 43 — Philadelphia, Pennsylvania
- Site 153 — Philadelphia, Pennsylvania
📞 Contact the Study Coordinator
Phone: (617) 401-4499
Email: USenquiries@merus.nl
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Head and Neck Squamous Cell Carcinoma
- Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma — Fullerton, California
- Testing the Addition of an Anti-cancer Drug, Ipatasertib, to the Usual Immunotherapy Treatment (Pembrolizumab) in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck — Duarte, California
- MIT-001 for Prevention of CCRT-Induced OM in HNSCC Patients — Gilbert, Arizona
- Study of Novel Treatment Combination Therapies in Participants With Head and Neck Squamous Cell Carcinoma Regardless of PD-L1 Expression Status; Substudy-01 — St Louis, Missouri
- Intensive Symptom Surveillance Guided by Machine Learning-Directed Risk Stratification in Patients With Non-Metastatic Head and Neck Cancer, The INSIGHT Trial — Buffalo, New York
- Neoadjuvant Targeting of Myeloid Cell Populations in Combination With Nivolumab in Head & Neck Ca — Baltimore, Maryland
Explore by condition: All Head and Neck Squamous Cell Carcinoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.