Is Conditioned Pain Modulation Predictive of Clinical Improvement in Patients With Chronic Low Back Pain? (NCT06544525)
🩺 Plain-English Summary (8th-Grade Level)
Conditioned pain modulation (CPM) a measure of the effectiveness of the descending pain pathway and therefore a measure of the body's ability to perform endogenous analgesia. In subjects with normal function of the descending pain pathway, the net-effect during CPM testing is anti-nociceptive, or inhibition of the ascending pain pathway. In those with impaired descending pain pathway function, the response to CPM testing is pro-nociceptive, indicating that the body is unable to inhibit the pain signal, or may even amplify it. There is literature that supports the presence of impaired CPM, and therefore impaired descending pain pathway function, in numerus chronic pain conditions, including low back pain. Impaired descending pain pathway function may be contributing to this chronic pain presentation. This study will give us information on whether a typical physical therapy plan of care is able to improve impaired CPM, and if CPM values are predictive of improvement in physical therapy.
Who can join: Review the eligibility criteria below.
Location: Brooke Army Medical Center — Fort Sam Houston, Texas
Age range: 18 Years to 64 Years
🧪 Interventions in This Study
- Physical therapy (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Brooke Army Medical Center — Fort Sam Houston, Texas
📞 Contact the Study Coordinator
Phone: (847) 274-2794
Email: kyle.r.petrey.mil@health.mil
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Low Back Pain
- Nonpharmacologic Pain Management in FQHC Primary Care Clinics — Salt Lake City, Utah
- Non-surgical Spinal Decompression Therapy and Outcomes — Stanford, California
- Non-pharmacological Treatment for Pain After Spine Surgery — Honolulu, Hawaii
- TeleYoga for Chronic Low Back Pain: A Quantitative and Qualitative Study — Kansas City, Kansas
- SMART Stepped Care Management for Low Back Pain in the Military Health System — Schofield Barracks, Hawaii
- Intracept Intraosseous Basivertebral Nerve Ablation — Farmington, Utah
Explore by condition: All Low Back Pain clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.