๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-05-21

Efficacy of Trastuzumab Deruxtecan in Metastatic Breast Cancer With Different HER2 Expression Patterns (NCT06551220)

HER2 Heterogeneity and Its Impact on Benefit From Trastuzumab Deruxtecan in Metastatic Breast Cancer

๐ŸŸข Recruiting Interventional Protocol ๐Ÿ“Š Observational Clinical Research Sponsor: Sun Yat-sen University

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The purpose of this observational study is to learn about the HER2 heterogeneity and its impact on benefit from trastuzumab deruxtecan in metastatic breast cancer. The main question it aims to answer is: \- Does the heterogeneity of HER2 expression level and spatial distribution in different tissues affect the efficacy of trastuzumab deruxtecan in metastatic breast cancer?

Who can join: Review the eligibility criteria below.

Location: Yale Cancer Center โ€” New Haven, Connecticut

Age range: 18 Years to 80 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (26 Sites)

Showing the first 25 of 26 sites.

  • Yale Cancer Center โ€” New Haven, Connecticut
  • Dana-Farber Cancer Institute, Harvard Medical School โ€” Boston, Massachusetts
  • Fujian Cancer Hospital, Fujian Medical University โ€” Fuzhou, Fujian
  • The 10th Affiliated Hospital of Southern Medical University โ€” Dongguan, Guangdong
  • The First People's Hospital of Foshan โ€” Foshan, Guangdong
  • The Sixth Affiliated Hospital, School of Medicine, South China University of Technology. โ€” Foshan, Guangdong
  • Sun Yat-sen University Cancer Center โ€” Guangzhou, Guangdong
  • The Affiliated Panyu Central Hospital, Guangzhou Medical University โ€” Guangzhou, Guangdong
  • Guangdong Provincial Hospital of Chinese Medicine โ€” Guangzhou, Guangdong
  • The Affiliated Cancer Hospital, Guangzhou Medical University โ€” Guangzhou, Guangdong
  • The First Affiliated Hospital of Guangzhou Medical University โ€” Guangzhou, Guangdong
  • The First Affiliated Hospital of Guangzhou University of Chinese Medicine โ€” Guangzhou, Guangdong
  • Cancer Hospital of Shantou University Medical College โ€” Shantou, Guangdong
  • Yuebei People's Hospital of Shantou University โ€” Shaoguan, Guangdong
  • National Cancer Center Shenzhen Hospital โ€” Shenzhen, Guangdong
  • Shenzhen People's Hospital โ€” Shenzhen, Guangdong
  • Zhongshan City People's Hospital โ€” Zhongshan, Guangdong
  • The Fifth Affiliated Hospital of Sun Yat-sen University โ€” Zhuhai, Guangdong
  • Changde Hospital, Xiangya School of Medicine, Central South University โ€” Changde, Hunan
  • Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University โ€” Changsha, Hunan
  • The Second Xiangya Hospital of Central South University โ€” Changsha, Hunan
  • The First Affiliated Hospital, Hengyang Medical School, University of South China โ€” Hengyang, Hunan
  • Affiliated Cancer Hospital of Inner Mongolia Medical University โ€” Hohhot, Inner Mongolia
  • The First Affiliated Hospital of Nanjing Medical University โ€” Nanjing, Jiangsu
  • Xinhua Hospital Afliated to Shanghai Jiaotong University โ€” Shanghai, Shanghai Municipality

๐Ÿ“ž Contact the Study Coordinator

Phone: 86-020-87343806

Email: xiexm@sysucc.org.cn

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—